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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Synthesis, antiplatelet and antithrombotic activities of resveratrol derivatives with NO-donor properties

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Author(s):
Dutra, Luiz Antonio ; Guanaes, Jessica Frade O. ; Johmann, Nadine ; Lopes Pires, Maria Elisa ; Chin, Chung Man ; Marcondes, Sisi ; Dos Santos, Jean Leandro
Total Authors: 7
Document type: Journal article
Source: Bioorganic & Medicinal Chemistry Letters; v. 27, n. 11, p. 2450-2453, JUN 1 2017.
Web of Science Citations: 11
Abstract

Resveratrol (RVT) is a stilbene with a protective effect on the cardiovascular system; however, drawbacks including low bioavailability and fast metabolism limit its efficacy. In this work we described new resveratrol derivatives with nitric oxide (NO) release properties, ability to inhibit platelet aggregation and in vivo antithrombotic effect. Compounds (4a-f) were able to release NO in vitro, at levels ranging from 24.1% to 27.4%. All compounds (2a-f and 4a-f) have exhibited platelet aggregation inhibition using as agonists ADP, collagen and arachidonic acid. The most active compound (4f) showed reduced bleeding time compared to acetylsalicylic acid (ASA) and protected up to 80% against in vivo thromboembolic events. These findings suggest that hybrid resveratrol-furoxan (4f) is a novel lead compound able to prevent platelet aggregation and thromboembolic events. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 15/19531-1 - Targeting histone deacetylase (HDAC-1 and HDAC-2) as mechanisms to induce fetal hemoglobin in sickle cell disease
Grantee:Jean Leandro dos Santos
Support Opportunities: Regular Research Grants
FAPESP's process: 11/15520-4 - Design, Synthesis and pharmacological evaluation of new compounds 1,2,5-oxadiazole-2-oxide useful as preventive of atherothrombosis.
Grantee:Luiz Antonio Dutra
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 15/21271-8 - Pharmacological evaluation of resveratrol derivatives as dual bromodomain/PPARs inhibitors to treat dyslipidemia
Grantee:Luiz Antonio Dutra
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 14/03945-9 - Design, synthesis and pharmacological evaluation of new resveratrol derivatives useful for dyslipidemia treatment
Grantee:Luiz Antonio Dutra
Support Opportunities: Scholarships in Brazil - Doctorate