| Full text | |
| Author(s): |
Diogo Tiago da Silva
;
Maria Luana Alves
[2]
;
Júlio Cesar Pereira Spada
;
Aline Cristine da Silva
[4]
;
Rita de Cássia Viveiros da Silveira
[5]
;
Trícia Maria Ferreira de Sousa Oliveira
[6]
;
Wilma Aparecida Starke-Buzetti
[7]
Total Authors: 7
|
| Document type: | Journal article |
| Source: | Revista Brasileira de Parasitologia Veterinária; v. 26, n. 2, p. 159-170, 2017-06-00. |
| Abstract | |
Abstract This study was about a semi-quantitative analysis of T lymphocytes (CD4+ and CD8+, FoxP3+ regulatory T cells), and macrophages in the gut wall of dogs naturally infected with Leishmania infantum. Thirteen dogs were divided into three groups: group 1 (G1, n=5), dogs with canine visceral leishmaniasis (CVL) and infected with L. infantum amastigotes in the intestine; group 2 (G2, n=5), dogs with CVL but without intestinal amastigotes; and group 3 (G3, n=3), uninfected dogs (control group). There was no significant difference (p ≥ 0.05) on CD4+ and Treg cell numbers among the groups, whereas the levels of CD8+ T cells and macrophages were significantly higher in dogs from G1 group than in G2 and G3 (p ≤ 0.05), especially in intestinal segments with high parasite burden. Parasite burden correlated positively with levels of CD8+ T cells and macrophages (p ≤ 0.05), but was inversely correlated to levels of CD4+ T lymphocytes and FoxP3+ Treg cells. In conclusion, in the intestine of dogs with CVL, the increase of CD8+ T cells and macrophages population associated with high parasite burdens, but no changes of CD4+ T cells and FoxP3+ Treg cells suggest a possible immunoregulation by the parasite not dependent on Treg cells. (AU) | |
| FAPESP's process: | 13/13875-5 - Correlation of the granulocytic and monocytic cell profiles in the intestine of dogs naturally infected with Leishmania infantum |
| Grantee: | Diogo Tiago da Silva |
| Support Opportunities: | Scholarships in Brazil - Master |