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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Expanding biological activities of Ts19 Frag-II toxin: Insights into IL-17 production

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Author(s):
Cerni, Felipe Augusto ; Pucca, Manuela Berto ; Zoccal, Karina Furlani ; Frantz, Fabiani Gai ; Faccioli, Lucia Helena ; Arantes, Eliane Candiani
Total Authors: 6
Document type: Journal article
Source: Toxicon; v. 134, p. 18-25, AUG 2017.
Web of Science Citations: 2
Abstract

Tityus serrulatus (Ts) venom is composed of a mixture of toxins presenting diverse biological functions. However, although this venom has been studied over the past three decades, omits analysis revealed that most of its toxins are not identified or their biological activities are unknown. Ts19 Frag-II is included in this group, which function is still uncertain. This study aimed to expand the biological activities of Ts19 Frag-II through in vivo investigation. Our results demonstrates that mice challenged with Ts19 Frag-II presented biochemical alterations, increasing serum levels of urea, ALT and beta-globulin, besides decreasing gamma-globulins. Moreover, this toxin was also able to induce immunological alterations, increasing NO, IL-6, TNF-alpha and IL-17, being considered a proinflammatory toxin. The increase of IL-17 was unprecedented regarding Ts toxins and could be a result of the overall produced-effect of cells of innate immunity cells (neutrophils, monocytes, natural killers and lymphoid tissue inducers - LTis) as well as of adaptive immunity (Th17 cells). This study expanded the biological activities of Ts19 Frag-II, suggesting that this toxin could be contributing to the Ts envenoming through alterations of biochemical parameters as well as triggering the inflammatory response. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 13/21329-0 - Electrophysiological characterization of Tityus serrulatus venom toxins Ts3, Ts4, Ts6, Ts8, Ts15 and TS venom peptide 7: looking for new desired drugs
Grantee:Manuela Berto Pucca
Support type: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 14/07125-6 - New functional aspects of eicosanoids
Grantee:Lúcia Helena Faccioli
Support type: Research Projects - Thematic Grants
FAPESP's process: 13/21342-7 - Electrophysiological characterization of Ts19 fragment II, a new toxin purified from Tityus serrulatus venom
Grantee:Felipe Augusto Cerni
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 14/03332-7 - Study of the relationship between inflammasome activation and lipid mediators production with pulmonary inflammation induced by scorpion venom with and without hyaluronidase
Grantee:Karina Furlani Zoccal
Support type: Scholarships in Brazil - Post-Doctorate