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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Glutamatergic and neural dysfunction in postpartum depression using magnetic resonance spectroscopy

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Rosa, Carlos E. ; Soares, Jair C. ; Figueiredo, Felipe P. ; Cavalli, Ricardo C. ; Barbieri, Marco A. ; Schaufelberger, Maristela S. ; Salmon, Carlos E. G. ; Del-Ben, Cristina M. ; Santos, Antonio C.
Total Authors: 9
Document type: Journal article
Source: PSYCHIATRY RESEARCH-NEUROIMAGING; v. 265, p. 18-25, JUL 30 2017.
Web of Science Citations: 13

Although postpartum depression (PPD) is a prevalent subtype of major depressive disorder, neuroimaging studies on PPD are rare, particularly those identifying neurochemical abnormalities obtained by proton magnetic resonance spectroscopy (H-1-MRS). The dorsolateral prefrontal (DLPF) and the anterior cingulate gyrus (ACG) are part of the neural pathways involved in executive functions and emotional processing, and both structures have been implicated in the neurobiology of depressive disorders. This study aimed to evaluate brain metabolites abnormalities in women with PPD compared with healthy postpartum (HP) women. Thirty-six PPD (34 without antidepressants) and 25 HP women underwent a H-1-MRS acquired on a 3-T MRI system, with the volume of interest positioned in ACG and DLPF. An ANCOVA was conducted with age, postpartum time, and contraceptive type as covariates. PPD group presented significantly lower Glutamate + Glutamine (Glx, -0.95 mM) and N-acetylaspartate + N-acetylaspartylglutamate (NAA, -0.60 mM) values in DLPF. There were no significant differences between groups in ACG, but we found a significant increase of Glutamate (Glu, 2.18 mM) and Glx (1.84 mM) in participants using progestogen-only contraceptives. These findings suggest glutamatergic dysfunction and neuronal damage in the DLPF of PPD patients, similarly to other subtypes of depressive disorders. Progestogens seem to interfere in the neurochemistry of ACG. (AU)

FAPESP's process: 08/53593-0 - Etiological factors of preterm birth and consequences of perinatal factors in child health: birth cohorts in two Brazilian cities (BRISA project)
Grantee:Marco Antonio Barbieri
Support type: Research Projects - Thematic Grants