Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genetic Polymorphism in MMP9 May Be Associated With Anterior Open Bite in Children

Full text
Author(s):
Show less -
Erika Calvano Küchler [1] ; Driely Barreiros [2] ; Raphaela Oliveira da Silva [3] ; Júlia Guimarães Barcellos de Abreu [4] ; Ellen Cardoso Teixeira [5] ; Raquel Assed Bezerra da Silva [6] ; Lea Assed Bezerra da Silva [7] ; Paulo Nelson Filho [8] ; Fábio Lourenço Romano [9] ; José Mauro Granjeiro [10] ; Lívia Azeredo Alves Antunes [11] ; Leonardo Santos Antunes
Total Authors: 12
Affiliation:
Show less -
[1] Universidade de São Paulo - Brasil
[2] Universidade de São Paulo - Brasil
[3] Universidade Federal Fluminense - Brasil
[4] Universidade Federal Fluminense - Brasil
[5] Universidade Federal Fluminense - Brasil
[6] Universidade de São Paulo - Brasil
[7] Universidade de São Paulo - Brasil
[8] Universidade de São Paulo - Brasil
[9] Universidade de São Paulo - Brasil
[10] Instituto Nacional de Metrologia, Qualidade e Tecnologia - Brasil
[11] Universidade Federal Fluminense - Brasil
Total Affiliations: 12
Document type: Journal article
Source: Brazilian Dental Journal; v. 28, n. 3, p. 277-280, 2017-06-00.
Abstract

Abstract Anterior open bite (AOB) has a multifactorial etiology caused by the interaction of sucking habits and genetic factors. The aim of this study was to evaluate the association between AOB and polymorphisms in genes that encode Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). Four hundred and seventy-two children that presented at least one sucking habit were evaluated. Children were examined clinically for the presence of AOB. Genomic DNA was extracted from saliva. Genotyping of the selected polymorphisms in MMP2, MMP3, MMP9, TIMP1 and TIMP2 was carried out by real-time PCR using the TaqMan method. Allele and genotype frequencies were compared between the groups with and without AOB using the PLINK® software in a free and in a recessive model using a chi-square test. Logistic regression analysis was implemented (p≤0.05). Two hundred nineteen children had AOB while 253 did not. The polymorphism rs17576 in MMP9 was significantly associated with AOB (p=0.009). In a recessive model GG genotype was a protective factor for AOB (p=0.014; OR 4.6, 95%CI 1.3-16.2). In the logistic regression analysis, none of the genes was associated with AOB. In conclusion, the polymorphism rs17576 (glutamine for arginine substitution) in MMP9 was a protective factor for AOB. (AU)

FAPESP's process: 15/06866-5 - Evaluation of the role of estrogen in dentofacial development
Grantee:Erika Calvano Kuchler
Support Opportunities: Research Grants - Young Investigators Grants