Understanding the biological function of natural products' scaffolds from database...
| Full text | |
| Author(s): |
Pilon, Alan C.
;
Valli, Marilia
;
Dametto, Alessandra C.
;
Pinto, Meri Emili F.
;
Freire, Rafael T.
;
Castro-Gamboa, Ian
;
Andricopulo, Adriano D.
;
Bolzani, Vanderlan S.
Total Authors: 8
|
| Document type: | Journal article |
| Source: | SCIENTIFIC REPORTS; v. 7, AUG 3 2017. |
| Web of Science Citations: | 23 |
| Abstract | |
The intrinsic value of biodiversity extends beyond species diversity, genetic heritage, ecosystem variability and ecological services, such as climate regulation, water quality, nutrient cycling and the provision of reproductive habitats it is also an inexhaustible source of molecules and products beneficial to human well-being. To uncover the chemistry of Brazilian natural products, the Nuclei of Bioassays, Ecophysiology and Biosynthesis of Natural Products Database (NuBBE(DB)) was created as the first natural product library from Brazilian biodiversity. Since its launch in 2013, the NuBBE(DB) has proven to be an important resource for new drug design and dereplication studies. Consequently, continuous efforts have been made to expand its contents and include a greater diversity of natural sources to establish it as a comprehensive compendium of available biogeochemical information about Brazilian biodiversity. The content in the NuBBE(DB) is freely accessible online (https://nubbe.iq.unesp.br/portal/nubbedb.html) and provides validated multidisciplinary information, chemical descriptors, species sources, geographic locations, spectroscopic data (NMR) and pharmacological properties. Herein, we report the latest advancements concerning the interface, content and functionality of the NuBBE(DB). We also present a preliminary study on the current profile of the compounds present in Brazilian territory. (AU) | |
| FAPESP's process: | 03/02176-7 - Conservation and sustainable use of the diversity from Cerrado and Atlantic Forest: chemical diversity and prospecting for potential drugs - phase II |
| Grantee: | Vanderlan da Silva Bolzani |
| Support type: | BIOTA-FAPESP Program - Thematic Grants |
| FAPESP's process: | 16/13292-8 - Analysis of nitrogen content in antropic influenced areas in Amazon and Atlantic Forest using a metabolomic tools |
| Grantee: | Alan Cesar Pilon |
| Support type: | Scholarships in Brazil - Post-Doctorate |
| FAPESP's process: | 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery |
| Grantee: | Glaucius Oliva |
| Support type: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |