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Analysis of nitrogen content in antropic influenced areas in Amazon and Atlantic Forest using a metabolomic tools

Grant number: 16/13292-8
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): February 01, 2017
Status:Discontinued
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Principal Investigator:Norberto Peporine Lopes
Grantee:Alan Cesar Pilon
Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:14/50265-3 - Distribution and metabolism of natural and synthetic xenobiotics: from the comprehension of reactional process to tissue imaging generation, AP.BTA.TEM
Associated scholarship(s):19/15889-0 - Plant traits and natural products databases combined the data mining for the modeling of functions and evolution of secondary metabolites in angiosperms, BE.EP.PD

Abstract

Biological diversity degradation due to anthropic effects in Brazilian tropical forests (Amazon and Atlantic Forest) is a historical issue and affects important ecological services for well-being human. The limited comprehension of its functioning and ability to promote ecological services makes the human-modified areas in tropical forests central points to researches related to biological conservation and climatic attenuation strategies. In this context, the project aims a better understanding about human-modified ecosystems, especially in tropical forests.I. Intellectual Merit: traditionally, morpho-physio-phenotypical characteristics are used as survival evaluation strategy (in plants) either in intact and perturbed ecosystems. Nevertheless exclusive use of such attributes neglects molecular phenomena that modulate all dynamic in organisms (from genes up to phenotypes) and, consequently the ecosystems. In this sense, this project aims the use metabolomic-based approaches to determination of biomarkers associated to plants survival strategy in intact and human-modified areas. The project focuses on qualitative and quantitative (relative) determination of nitrogen content (non-proteic) and its correlation with primary (nitrogen assimilation and aminoacids) and secondary (alkaloids, glucosamines, cyanogenic compounds) metabolism. II. Impact: considering the paradigm of sustainable use of natural resources, a fundamental premise of biological conservation programs, the approach aims to assist the comprehension of intact and degraded ecosystems by use of simple and robust methods of nitrogen content monitoring produced by distinct biosynthetic pathways.III. Integration: the integrative approach of this proposal involves researchers of Sao Paulo universities and institutes as well as international partners under different areas of knowledge with a common objective: to develop and apply methodologies in metabolomics for understanding of environmental degradation phenomena associated with human-modified areas. This proposal is essentially multidisciplinary and its ultimate goal is to promote knowledge for conservation and valuation of biodiversity. Box 1 shows the project structure with the main collaborations and their functions.

Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VALLI, MARILIA; RUSSO, HELENA MANNOCHIO; PILON, ALAN CESAR; FERREIRA PINTO, MERI EMILI; DIAS, NATHALIA B.; FREIRE, RAFAEL TEIXEIRA; CASTRO-GAMBOA, IAN; BOLZANI, VANDERLAN DA SILVA. Computational methods for NMR and MS for structure elucidation I: software for basic NMR. PHYSICAL SCIENCES REVIEWS, v. 4, n. 10 OCT 2019. Web of Science Citations: 1.
PILON, ALAN CESAR; GU, HAIWEI; RAFTERY, DANIEL; BOLZANI, VANDERLAN DA SILVA; LOPES, NORBERTO PEPORINE; CASTRO-GAMBOA, IAN; CARNEVALE NETO, FAUSTO. Mass Spectral Similarity Networking and Gas-Phase Fragmentation Reactions in the Structural Analysis of Flavonoid Glycoconjugates. Analytical Chemistry, v. 91, n. 16, p. 10413-10423, AUG 20 2019. Web of Science Citations: 1.
SELEGATO, DENISE MEDEIROS; FREIRE, RAFAEL TEIXEIRA; PILON, ALAN CESAR; BIASETTO, CAROLINA RABAL; DE OLIVEIRA, HAROLDO CESAR; DE ABREU, LUCAS MAGALHAES; ARAUJO, ANGELA REGINA; BOLZANI, VANDERLAN DA SILVA; CASTRO-GAMBOA, IAN. Improvement of bioactive metabolite production in microbial cultures-A systems approach by OSMAC and deconvolution-based (HNMR)-H-1 quantification. Magnetic Resonance in Chemistry, v. 57, n. 8, p. 458-471, AUG 2019. Web of Science Citations: 0.
CONDE-MARTINEZ, NATALIA; BAUERMEISTER, ANELIZE; PILON, ALAN CESAR; LOPES, NORBERTO PEPORINE; TELLO, EDISSON. Integrating Molecular Network and Culture Media Variation to Explore the Production of Bioactive Metabolites by Vibrio diabolicus A1SM3. MARINE DRUGS, v. 17, n. 4 APR 2019. Web of Science Citations: 0.
MOREIRA, DUARDA ANTUNES; PILON, ALAN CESAR; ANDRADE, LAURA ELENA; LOPES, NORBERTO PEPORINE. New Perspectives on Chlorogenic Acid Accumulation in Harvested Leaf Tissue: Impact on Traditional Medicine Preparations. ACS OMEGA, v. 3, n. 12, p. 18380-18386, DEC 2018. Web of Science Citations: 0.
MOREIRA, FERNANDA DE LIMA; MOREIRA, MARCELA DE LIMA; PILON, ALAN CESAR; LOPES, NORBERTO PEPORINE. . Planta Medica, v. 84, n. 15, p. 1141-1148, OCT 2018. Web of Science Citations: 1.
PILON, ALAN C.; VALLI, MARILIA; DAMETTO, ALESSANDRA C.; PINTO, MERI EMILI F.; FREIRE, RAFAEL T.; CASTRO-GAMBOA, IAN; ANDRICOPULO, ADRIANO D.; BOLZANI, VANDERLAN S. NuBBE(DB): an updated database to uncover chemical and biological information from Brazilian biodiversity. SCIENTIFIC REPORTS, v. 7, AUG 3 2017. Web of Science Citations: 21.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.