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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

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Galatro, Thais F. ; Holtman, Inge R. ; Lerario, Antonio M. ; Vainchtein, Ilia D. ; Brouwer, Nieske ; Sola, Paula R. ; Veras, Mariana M. ; Pereira, Tulio F. ; Leite, Renata E. P. ; Moller, Thomas ; Wes, Paul D. ; Sogayar, Mari C. ; Laman, Jon D. ; den Dunnen, Wilfred ; Pasqualucci, Carlos A. ; Oba-Shinjo, Sueli M. ; Boddeke, Erik W. G. M. ; Marie, Suely K. N. ; Eggen, Bart J. L.
Total Authors: 19
Document type: Journal article
Source: NATURE NEUROSCIENCE; v. 20, n. 8, p. 1162+, AUG 2017.
Web of Science Citations: 127
Abstract

Microglia are essential for CNS homeostasis and innate neuroimmune function, and play important roles in neurodegeneration and brain aging. Here we present gene expression profiles of purified microglia isolated at autopsy from the parietal cortex of 39 human subjects with intact cognition. Overall, genes expressed by human microglia were similar to those in mouse, including established microglial genes CX3CR1, P2RY12 and ITGAM (CD11B). However, a number of immune genes, not identified as part of the mouse microglial signature, were abundantly expressed in human microglia, including TLR, F-c gamma and SIGLEC receptors, as well as TAL1 and IFI16, regulators of proliferation and cell cycle. Age-associated changes in human microglia were enriched for genes involved in cell adhesion, axonal guidance, cell surface receptor expression and actin (dis)assembly. Limited overlap was observed in microglial genes regulated during aging between mice and humans, indicating that human and mouse microglia age differently. (AU)

FAPESP's process: 13/06315-3 - The role of microglia activation in human astrocytoma
Grantee:Suely Kazue Nagahashi Marie
Support type: Regular Research Grants
FAPESP's process: 13/07704-3 - The role of microglia activation in human astrocytoma
Grantee:Thais Fernanda de Almeida Galatro
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 13/02162-8 - Molecular pathogenesis and characterization of monogenic developmental diseases: a route to translational medicine
Grantee:Berenice Bilharinho de Mendonça
Support type: Research Projects - Thematic Grants