| Full text | |
| Author(s): |
Silva, Rafaela M.
;
Okano, Laura T.
;
Rodrigues, J. Augusto R.
;
Clososki, Giuliano C.
Total Authors: 4
|
| Document type: | Journal article |
| Source: | TETRAHEDRON-ASYMMETRY; v. 28, n. 7, p. 939-944, JUL 15 2017. |
| Web of Science Citations: | 2 |
| Abstract | |
We prepared various chiral alpha-alkyl, beta-aryl ketones with good to excellent enantiomeric excess through the Baker's yeast asymmetric double-bond reduction of the corresponding alpha,beta-unsaturated substrates adsorbed onto the resin Amberlite XAD-7. This methodology was compatible with substrates bearing both electron-donating and withdrawing groups attached to the aromatic ring. Elongation of the alpha-alkyl substituent of the starting material strongly affected the reactivity and enantioselectivity of the reaction. (C) 2017 Elsevier Ltd. All rights reserved. (AU) | |
| FAPESP's process: | 15/12811-9 - DIRECTED FUNCTIONALIZATION OF ARENES AND HETEROARENES AIMIMNG THE SYNTHESIS OF SUBSTANCES OF MEDICINAL INTEREST |
| Grantee: | Giuliano Cesar Clososki |
| Support Opportunities: | Regular Research Grants |