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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Extractive biocatalysis in the asymmetric reduction of alpha-alkyl, beta-aryl enones by Baker's yeast

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Author(s):
Silva, Rafaela M. ; Okano, Laura T. ; Rodrigues, J. Augusto R. ; Clososki, Giuliano C.
Total Authors: 4
Document type: Journal article
Source: TETRAHEDRON-ASYMMETRY; v. 28, n. 7, p. 939-944, JUL 15 2017.
Web of Science Citations: 2
Abstract

We prepared various chiral alpha-alkyl, beta-aryl ketones with good to excellent enantiomeric excess through the Baker's yeast asymmetric double-bond reduction of the corresponding alpha,beta-unsaturated substrates adsorbed onto the resin Amberlite XAD-7. This methodology was compatible with substrates bearing both electron-donating and withdrawing groups attached to the aromatic ring. Elongation of the alpha-alkyl substituent of the starting material strongly affected the reactivity and enantioselectivity of the reaction. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 15/12811-9 - DIRECTED FUNCTIONALIZATION OF ARENES AND HETEROARENES AIMIMNG THE SYNTHESIS OF SUBSTANCES OF MEDICINAL INTEREST
Grantee:Giuliano Cesar Clososki
Support Opportunities: Regular Research Grants