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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Albuminuria, renal function and blood pressure in undernourished children and recovered from undernutrition

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Author(s):
Martins, Vinicius J. B. ; Sesso, Ricardo ; Clemente, Ana P. G. ; Fernandes, Mariana B. F. ; Sawaya, Ana L.
Total Authors: 5
Document type: Journal article
Source: Pediatric Nephrology; v. 32, n. 9, p. 1555-1563, SEP 2017.
Web of Science Citations: 1
Abstract

Background The objective of this study was to investigate some biomarkers of renal function and blood pressure in children who had recovered from undernutrition. Methods This was cross-sectional, comparative study in which a convenience sample of children of both genders (n = 126; age range 6-16 years) treated at the Centre for Nutritional Recovery and Education (Sao Paulo, Brazil) was used. These children were classified into four groups for analysis: (1) children who were well nourished (control group; n = 50), (2) those showing stunted growth (stunted group; n = 22), (3) those who were underweight (underweight group; n = 23) and (4) those who had recovered from undernutrition (recovered group; n = 31). Results No between-group differences were found for mean levels of albuminuria, serum creatinine and cystatin C, and similar mean estimates of glomerular filtration rate (eGFR; using either creatinine, cystatin C or both). Almost 14% of the stunted group, 4% of the underweight group and 3% of the recovered group had albuminuria of >30 mg/g creatinine chi-square p = 0.034); none of the control children showed albuminuria of >30 mg/g creatinine. Mean systolic (SBP) and diastolic blood pressure (DBP) adjusted for age and gender of the children in the stunted {[} SBP (95% confidence interval): 92 (88-96) mmHg; DBP: 47 (44-49) mmHg] and recovered {[} SBP: 93 (90-96) mmHg; DBP: 49 (47-51) mmHg] groups were significantly lower than those of the controls {[} SBP: 98 (95-100) mmHg, P = 0.027; DBP: 53 (5255) mmHg, P = 0.001]. After additional adjustment for height, mean DBP remained significantly lower in the recovered group compared with the control group {[} 49 (46-51) vs. 53 (51-55) mmHg, respectively; P = 0.018). Logistic regression analysis showed that the stunted group had a 8.4-fold higher chance of developing albuminuria (>10 mg/g creatinine) than the control children (P = 0.006). Conclusions No alterations in renal function were found in underweight children and those who had recovered from undernutrition, whereas children with stunted growth presented with a greater risk for albuminuria. A lower DBP was found in children with stunted growth and those who had recovered from undernutrition. (AU)

FAPESP's process: 10/51237-2 - Effects of nutritional recovery on stress control, blood pressure and renal function
Grantee:Ana Lydia Sawaya
Support type: Regular Research Grants