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Interrelation of gamma-oryzanol and activation of adipose R1 and R2 adipose receptors: possible effect on improvement of obesity-associated renal function

Grant number: 15/10626-0
Support type:Regular Research Grants
Duration: February 01, 2016 - May 31, 2018
Field of knowledge:Health Sciences - Nutrition
Principal researcher:Camila Renata Corrêa
Grantee:Camila Renata Corrêa
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Assoc. researchers:Ana Lucia do Anjos Ferreira ; Igor Otavio Minatel

Abstract

Obesity is associated with several comorbidities such as dyslipidemia, hypertriglyceridemia, insulin resistance (IR) and diabetes mellitus type 2. Currently the literature reports that these comorbidities are directly related to oxidative stress and inflammation, situations that trigger an imbalance in production adipokine, or increase of proinflammatory cytokines and decrease adiponectin. This condition can cause renal and metabolic disorders, often associated with increased body weight. The ³-oryzanol, main phytosterol present in grains of rice, has shown potential antiadipogênica action, hypocholesterolemic, anti-inflammatory and antioxidant. Thus the aim of this study is to evaluate, in an animal model, the effects of ³-oryzanol on the activation of Adipo-R1 and Adipo-R2 receptors and their role in improvement of renal function. It will be used male Wistar rats (n = 60), 30 days old, from the Universidade Estadual Paulista (UNESP). Initially the animals are divided randomly into three groups to receive standard diet + water (n = 12 animals), fructose diet + 25% fructose in water (n = 36 animals) or fructose diet with ³-oryzanol + 25% fructose in water (n = 12 animals). After the development of albuminury (around 16 weeks), the animals of the FF group (n = 36) will be again divided to receive fructose diet + 25% fructose in water (n = 12 animals) or fructose diet with ³-oryzanol + 25% fructose in water (n = 12 animals) or a standard diet (n = 12 animals) for 8 weeks, totaling five independent experimental groups. Obesity is characterized by adiposity index and co-morbidities: blood pressure, blood glucose, lipid, hormonal and inflammatory serum profiles. They will be measured plasma levels of ³-oryzanol, total antioxidant capacity. In adipose tissue will be analyzed the inflammatory profile for ELISA. Renal function is evaluated by albuminury. It will analyze the inflammatory status and oxidative stress in renal tissue, transmission electron microscopy and morphological tissue study. (AU)

Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FRANCISQUETI-FERRON, FABIANE VALENTINI; GARCIA, JESSICA LEITE; TOGNERI FERRON, ARTUR JUNIO; NAKANDAKARE-MAIA, ERIKA TIEMI; GREGOLIN, CRISTINA SCHMITT; DAS CHAGAS SILVA, JANAINA PAIXAO; DOS SANTOS, KLINSMANN CAROLO; COLOMBO LO, ANGELO THOMPSON; SIQUEIRA, JULIANA SILVA; DE MATTEI, LETICIA; DE PAULA, BRUNO HENRIQUE; SARZI, FELIPE; VAGULA DE ALMEIDA SILVA, CAROL CRISTINA; MORETO, FERNANDO; COSTA, MARIANE ROVERO; FERREIRA, ANA LUCIA A.; MINATEL, IGOR OTAVIO; CORREA, CAMILA RENATA. Gamma-oryzanol as a potential modulator of oxidative stress and inflammation via PPAR-y in adipose tissue: a hypothetical therapeutic for cytokine storm in COVID-19?. Molecular and Cellular Endocrinology, v. 520, JAN 15 2021. Web of Science Citations: 0.
FRANCISQUETI, FABIANE VALENTINI; TOGNERI FERRON, ARTUR JUNIO; HASIMOTO, FABIANA KUROKAWA; RIZZI ALVES, PEDRO HENRIQUE; GARCIA, JESSICA LEITE; DOS SANTOS, KLINSMANN CAROLO; MORETO, FERNANDO; SILVA, VANESSA DOS SANTOS; FERREIRA, ANA LUCIA A.; MINATEL, IGOR OTAVIO; CORREA, CAMILA RENATA. Gamma Oryzanol Treats Obesity-Induced Kidney Injuries by Modulating the Adiponectin Receptor 2/PPAR-alpha Axis. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018. Web of Science Citations: 1.
FRANCISQUETI, FABIANE VALENTINI; MINATEL, IGOR OTAVIO; TOGNERI FERRON, ARTUR JUNIO; ZANATI BAZAN, SILMEIA GARCIA; SILVA, VANESSA DOS SANTOS; GARCIA, JESSICA LEITE; SALOME DE CAMPOS, DIJON HENRIQUE; FERREIRA, ANA LUCIA; MORETO, FERNANDO; CICOGNA, ANTONIO CARLOS; CORREA, CAMILA RENATA. Effect of Gamma-Oryzanol as Therapeutic Agent to Prevent Cardiorenal Metabolic Syndrome in Animals Submitted to High Sugar-Fat Diet. NUTRIENTS, v. 9, n. 12 DEC 2017. Web of Science Citations: 8.
FRANCISQUETI, FABIANE VALENTINI; NASCIMENTO, ANDRE FERREIRA; MINATEL, IGOR OTAVIO; DIAS, MARCOS CORREA; MELO LUVIZOTTO, RENATA DE AZEVEDO; BERCHIERI-RONCHI, CAROLINA; FERREIRA, ANA LUCIA A.; CORREA, CAMILA RENATA. Metabolic syndrome and inflammation in adipose tissue occur at different times in animals submitted to a high-sugar/fat diet. JOURNAL OF NUTRITIONAL SCIENCE, v. 6, AUG 21 2017. Web of Science Citations: 4.
DOS SANTOS, KLINSMANN CAROLO; BUENO, BIANCA GUERRA; PEREIRA, LUANA FERREIRA; FRANCISQUETI, FABIANE VALENTINI; BRAZ, MARIANA GOBBO; BINCOLETO, LAHIS FERNANDES; DA SILVA, LILIAN XAVIER; FERREIRA, ANA LUCIA A.; DE MELO STEVANATO NAKAMUNE, ANA CLAUDIA; CHEN, C. -Y. OLIVER; BLUMBERG, JEFFREY B.; CORREA, CAMILA RENATA. Yacon (Smallanthus sonchifolius) Leaf Extract Attenuates Hyperglycemia and Skeletal Muscle Oxidative Stress and Inflammation in Diabetic Rats. Evidence-based Complementary and Alternative Medicine, 2017. Web of Science Citations: 1.
FRANCISQUETI, FABIANE V.; SANTOS, KLINSMANN C.; FERRON, ARTUR J. T.; LO, ANGELO T. C.; MINATEL, IGOR O.; CAMPOS, DIJON H. S.; FERREIRA, ANA LUCIA A.; CORREA, CAMILA R. Fructose: Toxic effect on cardiorenal risk factors and redox state. SAGE OPEN MEDICINE, v. 4, JAN-DEC 2016. Web of Science Citations: 3.

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