The immunomodulation to diabetes control: New proposals for the reversion of this disease

Author(s)

Mancio, Rafael Dias ; Minatel, Elaine ; Cardoso, Mauricio de Almeida ; Khan, Barkat Ali ; Caldeira, Eduardo Jose

• Document type: Journal article
• Source: DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS; v. 9, n. 4, p. 210-212, OCT-DEC 2015.
• Web of Science Citations: 1

Abstract

The diabetes mellitus is a metabolic disorder, characterized by the hyperglycemia with deficiency in the use of carbohydrates, fats and proteins, resultant of the impairment in secretion and/or insulin action. Severely, the type 1 diabetes provokes the compromise of several organs, causing different disorders and until death of patient. In this way, the literature has shown the general treatments for the type 1 diabetes and currently the focus in immunotherapy and/or immunomodulation, to control of this hyperglycemic condition. The use of new therapies is necessary due to the high increase of incidence of this disease around the world. Recent studies showed an increase of 40% in the cases since 1997. This disease affects different organs, including the glandular tissues, mainly the pancreas. Despite all therapies for diabetes control, the damages occurred remain irreversible. Thus, in addition to general treatments, the use of immunotherapy may open new perspectives for treatment of this disease. Within this aspect, the anti-CD3 monoclonal antibodies may be effective, mainly by protect and maintain the pancreatic acinar cells. Thus, these treatments based in the immunomodulation can be an option for diabetes control and to reverse the damage caused by this disease. (C) 2015 Diabetes India. Published by Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 10/05455-8 - Effects of the anti-CD3 (OKT3) treatment in the salivary glands of spontaneous diabetic mice
• Grantee: Hugo Tadeu Metidieri
• Support Opportunities: Scholarships in Brazil - Scientific Initiation