| Full text | |
| Author(s): Show less - |
Barboza, Renato
;
Lima, Flavia Afonso
;
Reis, Aramys Silva
;
Murillo, Oscar Javier
;
Machado Peixoto, Erika Paula
;
Bandeira, Carla Leticia
;
Fotoran, Wesley Luzetti
;
Sardinha, Luis Roberto
;
Wunderlich, Gerhard
;
Bevilacqua, Estela
;
D'Imperio Lima, Maria Regina
;
Alvarez, Jose Maria
;
Maranhao Costa, Fabio Trindade
;
Goncalves, Ligia Antunes
;
Epiphanio, Sabrina
;
Farias Marinho, Cludio Romerso
Total Authors: 16
|
| Document type: | Journal article |
| Source: | SCIENTIFIC REPORTS; v. 7, AUG 17 2017. |
| Web of Science Citations: | 10 |
| Abstract | |
Malaria-associate pregnancy has a significant impact on infant morbidity and mortality. The detrimental effects of malaria infection during pregnancy have been shown to correlate with immune activation in the placental tissue. Herein we sought to evaluate the effect of Toll-like receptors (TLRs) activation on placental malaria (PM) development by using the Plasmodium berghei NK65(GFP) infection model. We observed that activation of the innate immune system by parasites leads to PM due to local inflammation. We identified TLR4 activation as the main pathway involved in the inflammatory process in the placental tissue since the absence of functional TLR4 in mice leads to a decrease in the pro-inflammatory responses, which resulted in an improved pregnancy outcome. Additionally, a similar result was obtained when infected pregnant mice were treated with IAXO-101, a TLR4/CD14 blocker. Together, this study illustrates the importance of TLR4 signalling for the generation of the severe inflammatory response involved in PM pathogenesis. Therefore, our results implicate that TLR4 blockage could be a potential candidate for therapeutic interventions to reduce malaria-induced pathology both in the mother and the fetus. (AU) | |
| FAPESP's process: | 12/16525-2 - Plasmodium vivax: pathogenesis and infectivity |
| Grantee: | Fabio Trindade Maranhão Costa |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 11/17880-8 - Toll-like receptors and NOD-like receptors in pregnancy-associated malaria pathogenesis: effects and mechanisms |
| Grantee: | Renato Barboza |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 14/20451-0 - The role of endothelial cells in the immunopathogenesis of murine malaria-associated ALI/ARDS: effects and mechanisms |
| Grantee: | Sabrina Epiphanio |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 14/09964-5 - The role of inflammasomes in the pathogenesis of malaria during pregnancy: effects and mechanisms |
| Grantee: | Cláudio Romero Farias Marinho |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/06106-0 - The role of inflammasomes in the pathogenesis of malaria during pregnancy: effects and mechanisms |
| Grantee: | Cláudio Romero Farias Marinho |
| Support Opportunities: | Research Grants - Visiting Researcher Grant - International |
| FAPESP's process: | 13/00981-1 - Characterization of the role of dendritic cells in the recrudescence of malaria in pregnancy |
| Grantee: | Oscar Javier Murillo Gómez |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 11/19048-8 - Role of Inflamassoma in the immunopathogenesis of Placental Malaria |
| Grantee: | Aramys Silva dos Reis |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 13/16417-8 - Autophagy in placental malaria: effects and mechanisms |
| Grantee: | Flávia Afonso Lima |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 09/53889-0 - Study of the immunopathological mechanisms involved in pregnancy-associated malaria |
| Grantee: | Cláudio Romero Farias Marinho |
| Support Opportunities: | Research Grants - Young Investigators Grants |