Caloric Restriction Promotes Structural and Metabolic Changes in the Skin

Author(s)

Forni, Maria Fernanda ; Peloggia, Julia ; Braga, Tarcio T. ; Ortega Chinchilla, Jesus Eduardo ; Shinohara, Jorge ; Navas, Carlos Arturo ; Saraiva Camara, Niels Olsen ; Kowaltowski, Alicia J.

• Document type: Journal article
• Source: CELL REPORTS; v. 20, n. 11, p. 2678-2692, SEP 12 2017.
• Web of Science Citations: 10

Abstract

Caloric restriction (CR) is the most effective intervention known to enhance lifespan, but its effect on the skin is poorly understood. Here, we show that CR mice display fur coat remodeling associated with an expansion of the hair follicle stem cell (HFSC) pool. We also find that the dermal adipocyte depot (dWAT) is underdeveloped in CR animals. The dermal/vennule annulus vasculature is enlarged, and a vascular endothelial growth factor (VEGF) switch and metabolic reprogramming in both the dermis and the epidermis are observed. When the fur coat is removed, CR mice display increased energy expenditure associated with lean weight loss and locomotion impairment. Our findings indicate that CR promotes extensive skin and fur remodeling. These changes are necessary for thermal homeostasis and metabolic fitness under conditions of limited energy intake, suggesting a potential adaptive mechanism. (AU)

• FAPESP's process: 10/51906-1 - Mitochondrial bioenergetics, ion transport, redox state and DNA metabolism
• Grantee: Alicia Juliana Kowaltowski
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 14/17270-3 - Impact of mitochondrial dysfunction on skin aging
• Grantee: Julia Peloggia de Castro
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 12/02270-2 - New cellular, molecular and immunological mechanisms involved in acute and chronic renal injury: the search for new therapeutical approaches
• Grantee: Niels Olsen Saraiva Câmara
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 13/04871-6 - Effects of caloric restriction on mitochondrial morphology, dynamics, bioenergetics and redox state
• Grantee: Maria Fernanda Pereira de Araújo Demonte Forni
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 14/16320-7 - Impacts of climate/environmental change on the fauna: an integrative approach
• Grantee: Carlos Arturo Navas Iannini
• Support Opportunities: Research Program on Global Climate Change - Thematic Grants
• FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
• Grantee: Ohara Augusto
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC