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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Teneurin-2 presence in rat and human odontoblasts

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Author(s):
Torres-da-Silvali, K. R. [1] ; Tessarin, G. W. L. [1] ; Dias, C. A. [2, 3] ; Guiati, I. Z. [2, 1] ; Ervolino, E. [2] ; Goncalves, A. [2] ; Beneti, I. M. [4] ; Lovejoy, D. A. [5] ; Casatti, C. A. [2, 1]
Total Authors: 9
Affiliation:
[1] Sao Paulo State Univ, Inst Biosci Botucatu, Botucatu, SP - Brazil
[2] Sao Paulo State Univ, Sch Dent Aracatuba, Basic Sci Dept, Aracatuba, SP - Brazil
[3] Sao Paulo State Univ, Sch Dent Aracatuba, Restorat Dent Dept, Aracatuba, SP - Brazil
[4] Sao Paulo State Univ, Sch Dent Aracatuba, Dept Surg & Integrated Clin, Aracatuba, SP - Brazil
[5] Univ Toronto, Cell & Syst Biol Dept, Toronto, ON - Canada
Total Affiliations: 5
Document type: Journal article
Source: PLoS One; v. 12, n. 9 SEP 19 2017.
Web of Science Citations: 3
Abstract

Teneurins are transmembrane proteins consisting of four paralogues (Ten-1-4), notably expressed in the central nervous system during development. All teneurins contain a bioactive peptide in their carboxyl terminal named teneurin C-terminal associated peptide (TCAP). The present study analyzed the detailed distribution of teneurin-2-like immunoreactive (Ten-2-LI) cells in developing and mature rat molar teeth, as well as in mature human dental pulps. Ten-2 and TCAP-2 genic expressions were also evaluated in rat and human dental pulps. Finally, Ten-2-LI cells were analyzed during the repair process after dentinpulp complex injury in rat lower molar teeth. For this, histological sections of rat molar teeth and human dental pulps were submitted to immunohistochemical techniques, while total RNA from developing rat teeth and mature human dental pulps were submitted to conventional RT-PCR. Ten-2-LI cells were evident in the initial bell stage of rat molar teeth development, especially in ectomesenchymal cells of the dental papilla. Ten-2-LI odontoblasts showed strong immunoreactivity in rat and human mature teeth. Ten-2 and TCAP-2 genic expressions were confirmed in rat and human dental pulps. Dentin-pulp complex injury resulted in a decrease of Ten-2-LI odontoblasts after traumatic injury. Interestingly, Ten-2-LI cells were also evident in the pulp cell-rich zone in all postoperative days. In conclusion, Ten-2-LI presence in rat and human odontoblasts was demonstrated for the first time and Ten-2/TCAP-2 genic expressions were confirmed in rat and human dental pulps. Furthermore, it was revealed that Ten-2-LI rat odontoblasts can be modulated during the regenerative process. (AU)

FAPESP's process: 12/08833-9 - Expression of teneurins and teneurins C-terminal associated peptides (TCAPs) in the central nervous system of non-human primates (Cebus apella)
Grantee:Kelly Regina Torres da Silva
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 12/03067-6 - Expression of teneurins (TEN) and teneurins C-terminal associated peptides (TCAP) in the central nervous system of non-human primates (Cebus apella)
Grantee:Cláudio Aparecido Casatti
Support Opportunities: Regular Research Grants
FAPESP's process: 13/01288-8 - Teneurins distribution in organs of the non-human primates and rodents
Grantee:Isabella Zacarin Guiati
Support Opportunities: Scholarships in Brazil - Scientific Initiation