Characterization of clinical predictors of naturally occurring NS3/NS4A protease polymorphism in genotype 1 hepatitis C virus mono and HIV co-infected patients

Author(s):Show less -

Neto, Gaspar Lisboa ^{[1, 2]} ; Malta, Fernanda M. ^[3] ; Gomes-Gouvea, Michele S. ^[3] ; Noble, Caroline F. ^[3] ; Romano, Camila M. ^[2] ; Rebello Pinho, Joao R. ^{[4, 3]} ; Silva, Mariliza H. ^{[5, 6]} ; Leite, Andrea G. B. ^[7] ; Piccoli, Leonora Z. ^[7] ; Carrilho, Flair J. ^[3] ; Mendes-Correa, Maria C. ^{[1, 2]}

Affiliation

^[1] Univ Sao Paulo, Sch Med, Dept Infect Dis, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Sch Med Sao Paulo, Inst Trop Med, Lab Virol LIM 52, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Med, Inst Trop Med, Lab Trop Gastroenterol & Hepatol LIM 07, Sao Paulo, SP - Brazil

^[4] Hosp Israelita Albert Einstein, Albert Einstein Med Diagnost, Sao Paulo, SP - Brazil

^[5] Ctr Referencia & Treinamento DST AIDS Estado Sao, Sao Paulo, SP - Brazil

^[6] Clin Especialidades, Sao Bernardo Do Campo, SP - Brazil

^[7] Ctr Especializado Saude, Caxias Do Sul, RS - Brazil

• Document type: Journal article
• Source: Journal of Medical Virology; v. 89, n. 12, p. 2249-2254, DEC 2017.
• Web of Science Citations: 1

Abstract

Spontaneously occurring resistance may impair the success of protease inhibitors based regimens in HCV treatment. This study aimed to evaluate associations between amino acid substitutions in NS3/NS4A domain and clinical features of 247 HCV mono or HCV/HIV co-infected patients. Fourteen samples (5.7%) harbored at least one resistance-associated substitution (RAS). The following RASs were detected in NS3 region: T54S (6-2.4%), V55A (7-2.8%), and Q80R (2-0.8%). S122G occurred in 86.9% of HCV genotype 1b samples with either natural polymorphisms or RASs. Advanced liver fibrosis and HIV co-infection were not related to NS3/NS4A amino acid substitutions. (AU)