Evaluation of the humoral response induced by Zika Virus infection using monoclona...
| Full text | |
| Author(s): Show less - |
Bernardes Terzian, Ana Carolina
[1]
;
Schanoski, Alessandra Soares
[2]
;
de Oliveira Mota, Minh' Tasso
[1]
;
da Silva, Rafael Alves
[1]
;
Estofolete, Cassia Fernanda
[1]
;
Colombo, Tatiana Elias
[1]
;
Rahal, Paula
[3]
;
Hanley, Kathryn A.
[4]
;
Vasilakis, Nikos
[5]
;
Kalil, Jorge
[6]
;
Nogueiral, Mauricio Lacerda
[1]
Total Authors: 11
|
| Affiliation: | [1] Sao Paulo State Univ, Sao Jose do Rio Preto Sch Med, Sao Jose Do Rio Preto - Brazil
[2] Sao Paulo State Univ, Butantan Inst, Sao Jose Do Rio Preto - Brazil
[3] Sao Paulo State Univ, Dept Biol, Inst Biosci Letters & Exact Sci, Sao Jose Do Rio Preto - Brazil
[4] New Mexico State Univ, Las Cruces, NM 88003 - USA
[5] Univ Texas Med Branch, Galveston, TX 77555 - USA
[6] Univ Sao Paulo, Sch Med, Sao Paulo - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | Clinical Infectious Diseases; v. 65, n. 8, p. 1260-1265, OCT 15 2017. |
| Web of Science Citations: | 41 |
| Abstract | |
Background. The pathogenesis of severe dengue disease involves immune components as biomarkers. The mechanism by which some dengue virus (DENV)-infected individuals progress to severe disease is poorly understood. Most studies on the pathogenesis of severe dengue disease focus on the process of antibody-dependent enhancement (ADE) as a primary risk factor. With the circulation of Zika virus (ZIKV) in DENV-endemic areas, many people infected by ZIKV were likely exposed to DENV. The influence of such exposure on Zika disease outcomes remains unknown. Methods. We investigated whether patients previously exposed to DENV exhibited higher viremia when exposed to a subsequent, heterologous dengue or Zika infection than those patients not previously exposed to dengue. We measured viral loads and cytokine profile during patients' acute infections. Results. Neither dengue nor Zika viremia was higher in patients with prior DENV infection, although the power to detect such a difference was only adequate in the ZIKV analysis. Of the 10 cytokines measured, only 1 significant difference was detected: Levels of interleukin 1 beta (IL-1 beta) were lower in dengue-infected patients who had experienced a previous dengue infection than patients infected with dengue for the first time. However, power to detect differences between groups was low. In Zika-infected patients, levels of IL-1 beta showed a significant, positive correlation with viral load. Conclusions. No signs of ADE were observed in vivo in patients with acute ZIKV infection who had prior exposure to DENV. (AU) | |
| FAPESP's process: | 13/21719-3 - Epidemiological study of dengue (serotypes1-4) in a cohort of São José do Rio Preto, São Paulo, Brazil, during 2014-2018 |
| Grantee: | Maurício Lacerda Nogueira |
| Support type: | Research Projects - Thematic Grants |
| FAPESP's process: | 15/12295-0 - Diagnostic of Brazilian and emergent arboviruses in patients and mosquitoes from two distinct regions in Brazil |
| Grantee: | Ana Carolina Bernardes Terzian |
| Support type: | Scholarships in Brazil - Post-Doctorate |