| Full text | |
| Author(s): |
Ramalho, F. N.
[1]
;
Sanches, S. C.
[1]
;
Foss, M. C.
[2]
;
Augusto, M. J.
[1]
;
Silva, D. M.
[1]
;
Oliveira, A. M.
[3]
;
Ramalho, L. N.
[1]
Total Authors: 7
|
| Affiliation: | [1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pathol & Legal Med, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Med, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Chem & Phys, Ribeirao Preto, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | DIABETOLOGY & METABOLIC SYNDROME; v. 9, OCT 13 2017. |
| Web of Science Citations: | 3 |
| Abstract | |
Background: Non-alcoholic steatohepatitis (NASH) is highly associated with metabolic syndrome, a major cause of morbidity in the globalized society. The renin-angiotensin system (RAS) influences hepatic fatty acid metabolism, inflammation and fibrosis. Thus, in the present study, we aimed to evaluate the effect of aliskiren, a direct renin inhibitor, on metabolic syndrome-related NASH. Methods: C57BL/6 male mice (n = 45) were divided into three groups: controls; animals inoculated with streptozotocin (STZ) (40 mg/kg/day) for 5 days and fed with high fat diet (HFD) for 8 weeks; and animals inoculated with STZ for 5 days, fed with HFD for 8 weeks and treated with aliskiren (100 mg/kg/day) for the final 2 weeks. Glycemic and insulin levels, hepatic lipid profile, histological parameters and inflammatory protein expression were analyzed. Results: Aliskiren normalized plasma glucose and insulin levels, reduced cholesterol, triglycerides and total fat accumulation in liver and diminished hepatic injury, steatosis and fibrosis. These results could be explained by the ability of aliskiren to block angiotensin-II, lowering oxidative stress and inflammation in liver. Also, it exhibited a beneficial effect in increasing insulin sensitivity. Conclusion: These findings support the use of aliskiren in the treatment of metabolic syndrome underlying conditions. However, clinical studies are indispensable to test its effectiveness in the treatment of patients with metabolic syndrome. (AU) | |
| FAPESP's process: | 10/20895-4 - Evaluation of AFB1-Lisin and AFB1-N7-guanin aducts as biomarkers of human and animal exposure to aflatoxins |
| Grantee: | Carlos Augusto Fernandes de Oliveira |
| Support Opportunities: | Research Projects - Thematic Grants |