Selective cytotoxicity and luminescence imaging of cancer cells with a dipicolinato-based Eu-III complex

Author(s)

Monteiro, J. H. S. K. ^{[1, 2]} ; Machado, D. ^[3] ; de Hollanda, L. M. ^[3] ; Lancellotti, M. ^[3] ; Sigoli, F. A. ^[1] ; de Bettencourt-Dias, A. ^[2]

Affiliation

^[1] Univ Estadual Campinas, Inst Chem, Sao Paulo - Brazil

^[2] Univ Nevada, Dept Chem, Reno, NV 89557 - USA

^[3] Univ Estadual Campinas, Inst Biol, Sao Paulo - Brazil

• Document type: Journal article
• Source: CHEMICAL COMMUNICATIONS; v. 53, n. 86, p. 11818-11821, NOV 7 2017.
• Web of Science Citations: 10

Abstract

Four new species {[}Ln(dipicNH(2))(3)](3-) (Ln = La-III, Eu-III, Gd-III, Tb-III), with the ligand dipicNH(2)(2-) (dipic = dipicolinato), were synthesized. Incubation of the Eu-III complex with glioma NG97 and pancreatic cancer PANC1 cells showed that it penetrates the cell membrane and can be used to image the cells, while also being moderately cytotoxic. (AU)

• FAPESP's process: 08/53868-0 - Synthesis and chacterization of novel materials strategically structured and organized to be applied in analytical and photonic devices
• Grantee: Lauro Tatsuo Kubota
• Support Opportunities: Research Projects - Thematic Grants