| Full text | |
| Author(s): |
Dias, Francisco Antunes
[1]
;
Alessio-Alves, Frederico Fernandes
[1]
;
Castro-Afonso, Luis Henrique
[2]
;
Cougo, Pedro Telles
[1]
;
Antunes Barreira, Clara Monteiro
[1]
;
Camilo, Millene Rodrigues
[1]
;
Nakiri, Guilherme Seizem
[2]
;
Abud, Daniel Giansante
[2]
;
Pontes-Neto, Octavio Marques
[1]
Total Authors: 9
|
| Affiliation: | [1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav Sci, Hosp Clin, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Hosp Clin, Radiol Div, Ribeirao Preto, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | JOURNAL OF STROKE & CEREBROVASCULAR DISEASES; v. 26, n. 10, p. 2191-2198, OCT 2017. |
| Web of Science Citations: | 7 |
| Abstract | |
Background: Intravenous thrombolysis (IVT) and endovascular therapy (EVT) were proven safe and effective for anterior circulation proximal occlusions. However, the most appropriate recanalization strategy in patients with acute basilar artery occlusion (BAO) is still controversial. This study aimed to assess outcomes of patients with BAO at an academic stroke center in Brazil. Methods: This is a retrospective analysis of consecutive patients with BAO from a prospective stroke registry at Ribeirao Preto Medical School. Primary outcomes were mortality and favorable outcome (modified Rankin score {[}mRS] <= 3) at 90 days. After univariate analyses, multivariate logistic regressions were used to identify independent predictors of primary outcomes. Results: Between August 2004 and December 2015, 63 (65% male) patients with BAO and median National Institutes of Health Stroke Scale (NIHSS) score of 31 (interquartile range: 19-36) were identified. Twenty-nine (46%) patients received no acute recanalization therapy, 15 (24%) received IVT, and 19 (30%) received EVT (68% treated with stent retrievers). Twenty-four (83%) patients treated conservatively died, and only 2 (7%) achieved an mRS less than or equal to 3. Among patients treated with acute recanalization therapies, 15 (44%) died, and 9 (26.5%) had a favorable outcome. On multivariate analysis, baseline systolic blood pressure (odds ratio {[}OR] = .97; 95% confidence interval {[}CI]:.95-0.99; P = .023), posterior circulation Alberta Stroke Program Early CT score (OR = .62; 95% CI:.41-0.94; P = .026), and successful recanalization (OR = .18; 95% CI:.04-0.71; P = .015) were independent predictors of lower mortality. Baseline NIHSS (OR = 1.40; 95% CI: 1.08-1.82; P = .012), prior use of statins (OR = .003; 95% CI:.001-0.28; P = .012), and successful recanalization (OR =.05; 95% CI:.001-0.27; P = .009) were independent predictors of favorable outcome. There was no significant difference between the IVT group and the EVT group on primary outcomes. Conclusions: BAO is associated with high morbidity and mortality in Brazil. Access to acute recanalization therapies may decrease mortality in those patients. (AU) | |
| FAPESP's process: | 16/15236-8 - Basilar artery international cooperation study |
| Grantee: | Octávio Marques Pontes-Neto |
| Support Opportunities: | Research Grants - Research in Public Policies for the National Health Care System (PP-SUS) |