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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The photodynamic efficiency of phenothiazinium dyes is aggregation dependent

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Francisco, Claudia M. L. [1] ; Goncalves, Jose M. L. A. [1] ; Brum, Bruno S. [1] ; Santos, Thabata P. C. [1] ; Lino-dos-Santos-Franco, Adriana [1] ; Silva, Daniela F. T. [1] ; Pavani, Christiane [1]
Total Authors: 7
[1] Univ Nove Julho UNINOVE, Programa Posgrad Biofoton Aplicada Ciencias Saude, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: NEW JOURNAL OF CHEMISTRY; v. 41, n. 23, p. 14438-14443, DEC 7 2017.
Web of Science Citations: 4

The evaluation of the IC50 values of phenothiazinium dyes in neoplastic immortalized cells (HeLa) in the dark and under irradiation showed that the effectiveness of the photosensitizers (PSs) increased in the order of Azure A (AA) < Azure B (AB) < Methylene Blue (MB). Singlet oxygen production was similar in all of the compounds and the cell uptake of MB was lower than those of AA and AB. The evaluation of the dimer to monomer ratio showed that aggregation increased in the order of MB < AB < AA. Thus, the photodynamic efficiency of these PSs was dependent on aggregation. In order to improve the effectiveness of photodynamic therapy (PDT), it is important to develop phenothiazinium dyes with structural modifications and/or to design formulations that could reduce aggregation. (AU)

FAPESP's process: 12/50680-5 - Photosensitization in life sciences
Grantee:Mauricio da Silva Baptista
Support type: Research Projects - Thematic Grants
FAPESP's process: 16/03037-0 - Photosensitizers aggregation and its consequences in photochemical mechanisms and Photodynamic Therapy effectivity
Grantee:Christiane Pavani
Support type: Regular Research Grants