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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Activity of gallic acid and its ester derivatives in Caenorhabditis elegans and zebrafish (Danio rerio) models

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Author(s):
Singulani, Junya de lacorte [1] ; Scorzoni, Liliana [1] ; Gomes, Paulo Cesar [1] ; Nazare, Ana Carolina [2] ; Polaquini, Carlos Roberto [2] ; Regasini, Luis Octavio [2] ; Fusco-Almeida, Ana Marisa [1] ; Soares Mendes-Giannini, Maria Jose [1]
Total Authors: 8
Affiliation:
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Clin Anal, Sao Paulo - Brazil
[2] Sao Paulo State Univ UNESP, Dept Chem & Environm Sci, Inst Biosci Humanities & Exact Sci, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Future Medicinal Chemistry; v. 9, n. 16, p. 1863-1872, OCT 2017.
Web of Science Citations: 6
Abstract

Aim: Gallic acid and its ester derivatives have shown antifungal activity in vitro. This study was performed to investigate their activity against Candida albicans and their toxicity in the animal models Caenorhabditis elegans and zebrafish embryos. Results: The compounds protected worms from C. albicans infection. The dodecyl gallate was the most effective. In zebrafish embryo, gallic acid and dodecyl gallate were the least toxic. Conclusion: Gallic acid and its ester derivatives have potential for in vivo use against C. albicans infection. The antifungal effects and toxicity of gallate esters in these alternative animal models were dependent on carbon chain length. (AU)

FAPESP's process: 15/03700-9 - Alternative animal as a model to study Paracoccidioides- host interaction: virulence, efficacy and toxicology of antifungal compounds and new preventive treatments
Grantee:Maria José Soares Mendes Giannini
Support type: Regular Research Grants
FAPESP's process: 13/10917-9 - Alternative animal models: Virulence of different phylogenetic species of Paracoccidioides and effect of the 30kDa 43kDa protein and their antibodies
Grantee:Liliana Scorzoni
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 14/10446-9 - Evaluation of new therapies and biomarkers in paracoccidioidomycosis: antifungal activity of alkyl gallates in alternative models and mice and identification of circulating microRNAs
Grantee:Junya de Lacorte Singulani
Support type: Scholarships in Brazil - Doctorate