Activity of gallic acid and its ester derivatives in Caenorhabditis elegans and zebrafish (Danio rerio) models

Author(s)

Singulani, Junya de lacorte ^[1] ; Scorzoni, Liliana ^[1] ; Gomes, Paulo Cesar ^[1] ; Nazare, Ana Carolina ^[2] ; Polaquini, Carlos Roberto ^[2] ; Regasini, Luis Octavio ^[2] ; Fusco-Almeida, Ana Marisa ^[1] ; Soares Mendes-Giannini, Maria Jose ^[1]

Affiliation

^[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Clin Anal, Sao Paulo - Brazil

^[2] Sao Paulo State Univ UNESP, Dept Chem & Environm Sci, Inst Biosci Humanities & Exact Sci, Sao Paulo - Brazil

• Document type: Journal article
• Source: Future Medicinal Chemistry; v. 9, n. 16, p. 1863-1872, OCT 2017.
• Web of Science Citations: 6

Abstract

Aim: Gallic acid and its ester derivatives have shown antifungal activity in vitro. This study was performed to investigate their activity against Candida albicans and their toxicity in the animal models Caenorhabditis elegans and zebrafish embryos. Results: The compounds protected worms from C. albicans infection. The dodecyl gallate was the most effective. In zebrafish embryo, gallic acid and dodecyl gallate were the least toxic. Conclusion: Gallic acid and its ester derivatives have potential for in vivo use against C. albicans infection. The antifungal effects and toxicity of gallate esters in these alternative animal models were dependent on carbon chain length. (AU)

• FAPESP's process: 14/10446-9 - Evaluation of new therapies and biomarkers in paracoccidioidomycosis: antifungal activity of alkyl gallates in alternative models and mice and identification of circulating microRNAs
• Grantee: Junya de Lacorte Singulani
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 15/03700-9 - Alternative animal as a model to study Paracoccidioides- host interaction: virulence, efficacy and toxicology of antifungal compounds and new preventive treatments
• Grantee: Maria José Soares Mendes Giannini
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/10917-9 - Alternative animal models: Virulence of different phylogenetic species of Paracoccidioides and effect of the 30kDa 43kDa protein and their antibodies
• Grantee: Liliana Scorzoni
• Support Opportunities: Scholarships in Brazil - Post-Doctoral