| Full text | |
| Author(s): |
FRANCISCO MAX DAMICO
[1]
;
FÁBIO GASPARIN
[2]
;
GABRIELA LOURENÇON IOSHIMOTO
[3]
;
THAIS ZAMUDIO IGAMI
[4]
;
ARMANDO DA SILVA CUNHA JR.
[5]
;
SILVIA LIGORIO FIALHO
[6]
;
ANDRE MAURICIO LIBER
[7]
;
LUCY HWA-YUE YOUNG
[8]
;
DORA FIX VENTURA
[9]
Total Authors: 9
|
| Affiliation: | [1] USP. Medical School. Department of Ophthalmology and Otolaryngology - Brasil
[2] USP. Medical School. Department of Ophthalmology and Otolaryngology - Brasil
[3] USP. Institute of Psychology. Department of Experimental Psychology - Brasil
[4] USP. Medical School. Department of Ophthalmology and Otolaryngology - Brasil
[5] UFMG. School of Pharmacy. Department of Pharmaceutic Products - Brasil
[6] Fundação Ezequiel Dias. Technologic Pharmaceutic Development Division - Brasil
[7] USP. Institute of Psychology. Department of Experimental Psychology - Brasil
[8] Harvard Medical School. Department of Ophthalmology - Estados Unidos
[9] USP. Institute of Psychology. Department of Experimental Psychology - Brasil
Total Affiliations: 9
|
| Document type: | Journal article |
| Source: | Rev. Col. Bras. Cir.; v. 44, n. 6, p. 603-611, 2017-12-00. |
| Abstract | |
ABSTRACT Objective : to determine the functional and morphological effects at rabbits retina of PS80 concentration used in the preparation of intravitreal drugs. Methods: eleven New Zealand rabbits received a intravitreal injection of 0.1ml of PS80. As control, the contralateral eye of each rabbit received the same volume of saline. Electroretinography was performed according to a modified protocol, as well as biomicroscopy and retina mapping before injection and seven and ten days after. Animals were euthanized in the 30th day and the retinas were analyzed by light microscopy. Results: eyes injected with PS80 did not present clinical signs of intraocular inflammation. Electroretinography did not show any alteration of extent and implicit time of a and b waves at scotopic and photopic conditions. There were no morphological alterations of retinas at light microscopy. Conclusion: intravitreal injection of PS80 in the used concentration for intravitreal drug preparations do not cause any functional or morphological alterations of rabbit retinas. These results suggest that PS80 is not toxic to rabbit retinas and may be safely used in the preparation of new lipophilic drugs for intravitreal injection. (AU) | |
| FAPESP's process: | 14/26818-2 - Development and implementation of visual evaluation methods: clinical applications and animal models |
| Grantee: | Dora Selma Fix Ventura |
| Support Opportunities: | Research Projects - Thematic Grants |