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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Proteomic approaches for drug discovery against tegumentary leishmaniasis

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Author(s):
Negrao, Fernanda [1, 2] ; Eberlin, Marcos Nogueira [1] ; Giorgio, Selma [2]
Total Authors: 3
Affiliation:
[1] Univ Estadual Campinas, UNICAMP, Inst Chem, ThoMSon Mass Spectrometry Lab, BR-13083970 Campinas, SP - Brazil
[2] Univ Estadual Campinas, UNICAMP, Inst Biol, Dept Anim Biol, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 2
Document type: Review article
Source: BIOMEDICINE & PHARMACOTHERAPY; v. 95, p. 577-582, NOV 2017.
Web of Science Citations: 4
Abstract

Tegumentary leishmaniases (TL) comprise various clinical forms, in which current therapeutic treatments lack in safety and efficacy. Recently the parasite is developing resistance mechanisms against anti leishmanial drugs startling the scientific community to recruit efforts to search for novel therapeutics. Proteomics hold promises for the treatment of leishmaniasis and investigation of parasite-host interaction since these set of methodological tools have provided a wealth of protein expression data on several Leishmania species. Firstly this review puts together the current treatment and challenges to fight tegumentary leishmaniasis. In addition, the 2 dimensional gel electrophoresis and mass spectrometry techniques in protein identification and characterization are described and discussed in the context of proteomics regarding Leishmania studies. In this review, we selected literature content on TL causative agents. Important proteomic findings related to differentiation proteome (promastigote and amastigote forms), Leishmania-macrophage interaction proteome and secreted and soluble proteins including molecules involved in parasite resistance and potential drug targets are examined and discussed. We also highlight open questions regarding drug research that can be addressed with proteomics approaches. (AU)

FAPESP's process: 16/11517-2 - Cutaneous leishmaniasis biomarkers candidates search and identification through mass spectrometry
Grantee:Fernanda Negrão Silva
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 15/23767-0 - Development of biomarkers and Leishmania infantum strains
Grantee:Selma Giorgio
Support Opportunities: Regular Research Grants