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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Latent tuberculosis infection screening in juvenile idiopathic arthritis patients preceding anti-TNF therapy in a tuberculosis high-risk country

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Author(s):
Brunelli, Juliana Barbosa [1] ; Bonfiglioli, Karina Rossi [2] ; Silva, Clovis A. [1] ; Kozu, Katia Tomie [1] ; Goldenstein-Schainberg, Claudia [2] ; Bonfa, Eloisa [2] ; Aikawa, Nadia Emi [1, 2]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Fac Med, Unidade Reumatol Pediat, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Med, Div Reumatol, Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: REVISTA BRASILEIRA DE REUMATOLOGIA; v. 57, n. 5, p. 392-396, SEP-OCT 2017.
Web of Science Citations: 5
Abstract

Abstract Objectives: To evaluate, in an endemic country, the long-term efficacy of latent tuberculosis infection (LTBI) screening and primary prophylaxis in patients with JIA receiving TNF blockers. Methods: This was a retrospective cohort that included JIA patients eligible to anti-TNF therapy. Patients were screened for LTBI prior to anti-TNF using tuberculin skin test (TST), chest X-ray and history of exposure to TB. Subjects were regularly followed at 2-month intervals. Results: Sixty-nine JIA patients with current age of 17.4 ± 5.8 years, mean disease duration of 5.0 ± 4.9 years were included. Forty-seven patients received a single anti-TNF, while 22 patients switched to another anti-TNF once or twice: 57 were treated with etanercepte, 33 patients with adalimumab and 3 infliximab. LTBI screening was positive in three patients: one had TST-positive and history of TB exposure and two had solely TST-positive. No active TB was diagnosed during the study period (median of follow-up was 3.8 years). Conclusion: Long-term evaluation revealed that LTBI screening and primary prophylaxis before anti-TNF treatment was effective in a high-risk country and TST was the most sensitive parameter to identify these patients. (AU)

FAPESP's process: 14/14806-0 - Evaluation of ovarian reserve, antibody anti-corpus luteum, cervicovaginal cytology, lower genital tract infections, metabolomics and ovulatory dysfunction in women with juvenile idiopathic arthritis
Grantee:Clovis Artur Almeida da Silva
Support Opportunities: Regular Research Grants