Comparison of the performance among three screening tests (skin tuberculin test, P...
Comparision of the performance among three screening tests (skin tuberculin test, ...
Full text | |
Author(s): |
Brunelli, Juliana Barbosa
[1]
;
Bonfiglioli, Karina Rossi
[2]
;
Silva, Clovis A.
[1]
;
Kozu, Katia Tomie
[1]
;
Goldenstein-Schainberg, Claudia
[2]
;
Bonfa, Eloisa
[2]
;
Aikawa, Nadia Emi
[1, 2]
Total Authors: 7
|
Affiliation: | [1] Univ Sao Paulo, Fac Med, Unidade Reumatol Pediat, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Med, Div Reumatol, Sao Paulo, SP - Brazil
Total Affiliations: 2
|
Document type: | Journal article |
Source: | REVISTA BRASILEIRA DE REUMATOLOGIA; v. 57, n. 5, p. 392-396, SEP-OCT 2017. |
Web of Science Citations: | 5 |
Abstract | |
Abstract Objectives: To evaluate, in an endemic country, the long-term efficacy of latent tuberculosis infection (LTBI) screening and primary prophylaxis in patients with JIA receiving TNF blockers. Methods: This was a retrospective cohort that included JIA patients eligible to anti-TNF therapy. Patients were screened for LTBI prior to anti-TNF using tuberculin skin test (TST), chest X-ray and history of exposure to TB. Subjects were regularly followed at 2-month intervals. Results: Sixty-nine JIA patients with current age of 17.4 ± 5.8 years, mean disease duration of 5.0 ± 4.9 years were included. Forty-seven patients received a single anti-TNF, while 22 patients switched to another anti-TNF once or twice: 57 were treated with etanercepte, 33 patients with adalimumab and 3 infliximab. LTBI screening was positive in three patients: one had TST-positive and history of TB exposure and two had solely TST-positive. No active TB was diagnosed during the study period (median of follow-up was 3.8 years). Conclusion: Long-term evaluation revealed that LTBI screening and primary prophylaxis before anti-TNF treatment was effective in a high-risk country and TST was the most sensitive parameter to identify these patients. (AU) | |
FAPESP's process: | 14/14806-0 - Evaluation of ovarian reserve, antibody anti-corpus luteum, cervicovaginal cytology, lower genital tract infections, metabolomics and ovulatory dysfunction in women with juvenile idiopathic arthritis |
Grantee: | Clovis Artur Almeida da Silva |
Support Opportunities: | Regular Research Grants |