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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Reduced salivary flow rate and high levels of oxidative stress in whole saliva of children with Down syndrome

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Author(s):
Domingues, Natalia Bertolo [1] ; Mariusso, Matheus Racy [1] ; Tanaka, Marcia Hiromi [2] ; Scarel-Caminaga, Raquel Mantuaneli [3] ; Alves Mayer, Marcia Pinto [4] ; Brighenti, Fernanda Lourencao [1] ; Cilense Zuanon, Angela Cristina [1] ; Ibuki, Flavia Kazue [5] ; Nogueira, Fernando Neves [5] ; Aparecida Giro, Elisa Maria [1]
Total Authors: 10
Affiliation:
[1] UNESP, Univ Estadual Paulista, Araraquara Dent Sch, Dept Orthodont & Pediat Dent, Araraquara, Sao Paulo - Brazil
[2] UNESP, Univ Estadual Paulista, Inst Sci & Technol Sao Jose Dos Campos, Dept Microbiol, Sao Jose Dos Campos, Sao Paulo - Brazil
[3] UNESP, Univ Estadual Paulista, Araraquara Dent Sch, Dept Morphol, Araraquara, Sao Paulo - Brazil
[4] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo, Sao Paulo - Brazil
[5] Univ Sao Paulo, Dept Biomat & Oral Biol, Sao Paulo, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: SPECIAL CARE IN DENTISTRY; v. 37, n. 6, p. 269-276, NOV-DEC 2017.
Web of Science Citations: 2
Abstract

Aim: To investigate salivary parameters between children with Down Syndrome (DS) and without DS. Materials and Methods: Stimulated whole saliva was collected from 18 children with DS and 23 without DS. Salivary flow rate, pH, and salivary buffering capacity were determined. Cariogenic microorganisms were quantified by culture, and periodontopathogens by quantitative real-time polymerase chain reaction. The antioxidant profile was quantified spectrophotometrically, while malondialdehyde (MDA) was quantified by high-performance liquid chromatography. Data were analyzed by Mann-Whitney test and Spearman correlation (alpha = 0.05). Results: Salivary flow rate was significantly lower in DS than in controls (p < 0.0001). Significant higher difference was observed for total protein dosage (p < 0.0001), superoxide dismutase activity (SOD) (p = 0.0002), and MDA (p < 0.001) in DS group. Conclusions: Reduced salivary flow rate might be an important factor in oral diseases development.High salivary levels of SOD and MDA show the significant influence of the oxidative stress and the early-onset periodontal disease in DS people. (AU)

FAPESP's process: 13/18010-2 - Salivary components and factors related to dental caries and periodontal disease in children with Down Syndrome
Grantee:Natália Bertolo Domingues
Support Opportunities: Scholarships in Brazil - Master