Nutrimiromics: Role of microRNAs and Nutrition in Modulating Inflammation and Chronic Diseases

Author(s)

Quintanilha, Bruna J. ^{[1, 2]} ; Reis, Bruna Z. ^[3] ; Silva Duarte, Graziela B. ^[3] ; Cozzolino, Silvia M. F. ^[3] ; Rogero, Marcelo M. ^{[1, 2]}

Affiliation

^[1] Univ Sao Paulo, Nutr Genom & Inflammat Lab, Dept Nutr, Sch Publ Hlth, BR-01246904 Sao Paulo - Brazil

^[2] Food Res Ctr FoRC, BR-05508000 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept Food & Expt Nutr, Nutr & Minerals Lab, BR-05508000 Sao Paulo - Brazil

• Document type: Review article
• Source: NUTRIENTS; v. 9, n. 11 NOV 2017.
• Web of Science Citations: 17

Abstract

Nutrimiromics studies the influence of the diet on the modification of gene expression due to epigenetic processes related to microRNAs (miRNAs), which may affect the risk for the development of chronic diseases. miRNAs are a class of non-coding endogenous RNA molecules that are usually involved in post-transcriptional gene silencing by inducing mRNA degradation or translational repression by binding to a target messenger RNA. They can be controlled by environmental and dietary factors, particularly by isolated nutrients or bioactive compounds, indicating that diet manipulation may hold promise as a therapeutic approach in modulating the risk of chronic diseases. This review summarizes the evidence regarding the influence of nutrients and bioactive compounds on the expression of miRNAs related to inflammation and chronic disease in several models (cell culture, animal models, and human trials). (AU)

• FAPESP's process: 15/02906-2 - Effect of supplementation with brazil nut (Bertholettia excelsa H.B.K) on inflammation, oxidative stress and the expression of selenoprotein p and microRNAs in obese women
• Grantee: Silvia Maria Franciscato Cozzolino
• Support Opportunities: Regular Research Grants