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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Histological analysis of the association of low level laser therapy and platelet-rich plasma in regeneration of muscle injury in rats

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Author(s):
Garcia, Thiago Alves [1] ; Trindade Camargo, Regina Celi [2] ; Koike, Tatiana Emy [2] ; Tamura Ozaki, Guilherme Akio [1] ; Castoldi, Robson Chacon [1] ; Silva Camargo Filho, Jose Carlos [2]
Total Authors: 6
Affiliation:
[1] Univ Estadual Campinas, UNICAMP, Programa Posgrad Ciencias Cirurgia, Campinas, SP - Brazil
[2] Univ Estadual Paulista, UNESP, Dept Fisioterapia, Presidente Prudente, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: BRAZILIAN JOURNAL OF PHYSICAL THERAPY; v. 21, n. 6, p. 425-433, NOV-DEC 2017.
Web of Science Citations: 5
Abstract

Objective: Muscle injuries are common, and their treatment requires costs and time off. Platelet rich plasma and low level laser therapy have been shown to be affordable and easy to use. The aim of this study was to evaluate the associated effects of low level laser therapy and platelet rich plasma on the treatment of the soleus muscle injured by strain in rats.\& para;\& para;Methods: Thirty-five rats were randomly allocated into five groups: Control (C), Injury Control (IC), injury PRP (IP), injury LLLT (ILT) and injury LILT and PRP (ILTP). The strain injury was induced in the soleus muscle and the IP group received application of platelet rich plasma immediately after the lesion, while the ILT group received low level laser therapy. After seven days, all animals were euthanized and the soleus muscle removed for further histological analysis.\& para;\& para;Results: The association of both treatments (ILTP) resulted in better histological aspects than the low level laser therapy and platelet rich plasma alone, when compared with the injury group (IC). The collagen analysis exhibited a significant increase in the ILT group (2.99 SD = 1.13) compared to the C (1.88 SD = 0.41, p = 0.012) and IP (2.04 SD = 0.44, p = 0.018).\& para;\& para;Conclusion: The association of low level laser therapy with platelet rich plasma produced better results on muscle injury compared to the isolated use of these therapies. Furthermore, none of the treatments could modulate the collagen deposition in relation to injury group. (C) 2017 Associacao Brasileira de Pesquisa e Pos-Graduacao em Fisioterapia. Published by Elsevier Editora Ltda. All rights reserved. (AU)

FAPESP's process: 14/10086-2 - Histological analysis of the effects of low intensity laser therapy, platelet rich plasma, and the combination of both, in regeneration of muscle tissue of rats
Grantee:Thiago Alves Garcia
Support Opportunities: Scholarships in Brazil - Scientific Initiation