Innate immune response in neonate Holstein heifer calves fed fresh or frozen colostrum

Author(s)

Dos Reis Costa, Juliana Franca ^{[1, 2]} ; Fontes Novo, Sylvia Marquart ^{[1, 2]} ; Baccili, Camila Costa ^{[1, 2]} ; Sobreira, Natalia Meirelles ^{[1, 2]} ; Hurley, David John ^[3] ; Gomes, Viviani ^[1]

Affiliation

^[1] Univ Sao Paulo, Coll Vet Med & Anim Sci, Dept Internal Med, Sao Paulo, SP - Brazil

^[2] Av Prof Dr Orlando Marques de Paiva 87, BR-05508270 Sao Paulo, SP - Brazil

^[3] Univ Georgia, Coll Vet Med, Food Anim Hlth & Management Program, Athens, GA 30602 - USA

• Document type: Journal article
• Source: Research in Veterinary Science; v. 115, p. 54-60, DEC 2017.
• Web of Science Citations: 1

Abstract

The aim of this research was to evaluate the influence of maternal cells from colostrum on the development and function of the innate immune response in Holstein calves. Calves were divided into 2 groups: COL+ (n = 10) received fresh colostrum; and COL (n = 10) which received frozen colostrum containing no viable cells. The calves were assessed before colostrum intake (DO), 48 h of age (D2), and weekly from D7 up to D28. Blood samples were collected for analysis of the distribution of leukocytes, cellular phenotype and in vitro granulocyte function. COL + calves tended to have a high number of neutrophils on D7 (p = 0.073). COL calves took up significantly more Escherichia coli (measured as MFI) on D7 (p = 0.034). Endogenous production of radicals (as percentage of cells) tended to be higher in COL calves on D14 (p = 0.061). The intensity of endogenous reactive oxygen species (ROS) produced by granulocytes tended to be higher in COL+ calves on D21 (p = 0.094). Overall, ROS production (percent of cells, and MFI) induced by Staphylococcus aureus and Escherichia coli were higher in COL+ calves than COL calves. It was our observation that COL+ calves developed an innate immune response more quickly and efficiently after natural exposure to pathogens after birth. In contrast, COL calves mounted an innate response more slowly that yielded a persistent inflammatory response after natural exposure to these bacteria agents. This research provides evidence of an advantage to the calf of receiving fresh colostrum on the development and function of the innate immune system. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 13/06152-7 - Effect of leukocytes colostrum mother in immune response of newborn calves
• Grantee: Viviani Gomes
• Support Opportunities: Regular Research Grants