| Full text | |
| Author(s): |
Costa, L. da F.
;
Barbosa, M. S.
[2]
;
Manoel, E. T. M.
;
Streicher, J.
;
Müller, G. B.
Total Authors: 5
|
| Document type: | Journal article |
| Source: | Bioinformatics; v. 20, n. 11, p. 1653-1662, Jul. 2004. |
| Field of knowledge: | Physical Sciences and Mathematics - Computer Science |
| Abstract | |
The importance of a systematic methodology for the mathematical characterization of three-dimensional gene expression patterns in embryonic development. By combining lacunarity and multiscale fractal dimension analyses with computer-based methods of three-dimensional reconstruction, it becomes possible to extract new information from in situ hybridization studies. Lacunarity and fractality are appropriate measures for the cloud-like gene activation signals in embryonic tissues. The newly introduced multiscale method provides a natural extension of the fractal dimension concept, being capable of characterizing the fractality of geometrical patterns in terms of spatial scale. This tool can be systematically applied to three-dimensional patterns of gene expression. Applications are illustrated using the three-dimensional expression patterns of the myogenic marker gene Myf5 in a series of differentiating somites of a mouse embryo. (AU) | |
| FAPESP's process: | 02/02504-1 - Dynamic shape analysis |
| Grantee: | Marconi Soares Barbosa |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 99/12765-2 - Development and assessment of novel and accurate methods in shape analysis and computer vision |
| Grantee: | Luciano da Fontoura Costa |
| Support Opportunities: | Research Projects - Thematic Grants |