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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Mathematical characterization of three-dimensional gene expression patterns

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Author(s):
Costa, L. da F. ; Barbosa, M. S. [2] ; Manoel, E. T. M. ; Streicher, J. ; Müller, G. B.
Total Authors: 5
Document type: Journal article
Source: Bioinformatics; v. 20, n. 11, p. 1653-1662, Jul. 2004.
Field of knowledge: Physical Sciences and Mathematics - Computer Science
Abstract

The importance of a systematic methodology for the mathematical characterization of three-dimensional gene expression patterns in embryonic development. By combining lacunarity and multiscale fractal dimension analyses with computer-based methods of three-dimensional reconstruction, it becomes possible to extract new information from in situ hybridization studies. Lacunarity and fractality are appropriate measures for the cloud-like gene activation signals in embryonic tissues. The newly introduced multiscale method provides a natural extension of the fractal dimension concept, being capable of characterizing the fractality of geometrical patterns in terms of spatial scale. This tool can be systematically applied to three-dimensional patterns of gene expression. Applications are illustrated using the three-dimensional expression patterns of the myogenic marker gene Myf5 in a series of differentiating somites of a mouse embryo. (AU)

FAPESP's process: 02/02504-1 - Dynamic shape analysis
Grantee:Marconi Soares Barbosa
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 99/12765-2 - Development and assessment of novel and accurate methods in shape analysis and computer vision
Grantee:Luciano da Fontoura Costa
Support type: Research Projects - Thematic Grants