Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence

Author(s):Show less -

de Araujo, Celia Maria ^{[1, 2]} ; Zugman, Andre ^{[1, 2]} ; Swardfager, Walter ^{[3, 4]} ; Nogueira Belangero, Sintia Iole ^{[5, 1, 2]} ; Ota, Vanessa Kiyomi ^{[5, 1]} ; Spindola, Leticia Maria ^{[5, 1]} ; Hakonarson, Hakon ^[6] ; Pellegrino, Renata ^[6] ; Gadelha, Ary ^{[1, 2]} ; Salum, Giovanni Abrahao ^{[2, 7]} ; Pan, Pedro Mario ^{[1, 2]} ; de Moura, Luciana Monteiro ^[8] ; Del Aquilla, Marco ^{[1, 2]} ; Picon, Felipe Almeida ^{[2, 7]} ; Amaro, Jr., Edson ^[9] ; Sato, Joao Ricardo ^{[2, 8]} ; Brietzke, Elisa ^[1] ; Grassi-Oliveira, Rodrigo ^[10] ; Rohde, Luis Augusto P. ^{[2, 7]} ; Miguel, Euripedes Constantino ^{[2, 11]} ; Bressan, Rodrigo A. ^{[1, 2]} ; Jackowski, Andrea Parolin ^{[1, 2]}

Affiliation:Show less -

^[1] Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo - Brazil

^[2] Natl Inst Dev Psychiat Children & Adolescents INC, Sao Paulo - Brazil

^[3] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON - Canada

^[4] Sunnybrook Res Inst, Hurvitz Brain Sci Program, Toronto, ON - Canada

^[5] Univ Fed Sao Paulo, Dept Morphol & Genet, Sao Paulo - Brazil

^[6] Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 - USA

^[7] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Dept Psychiat, Porto Alegre, RS - Brazil

^[8] Univ Fed ABC, Math & Stat Inst, Santo Andre - Brazil

^[9] Univ Sao Paulo, Inst Radiol INRAD, Sao Paulo - Brazil

^[10] Pontificia Univ Catolica Rio Grande do Sul, DCNL, Porto Alegre, RS - Brazil

^[11] Univ Sao Paulo, Dept & Inst Psychiat IPq, Sao Paulo - Brazil

• Document type: Journal article
• Source: JOURNAL OF PSYCHIATRIC RESEARCH; v. 98, p. 51-58, MAR 2018.
• Web of Science Citations: 6

Abstract

Background: The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism (rs6265) has been associated with several neuropsychiatric disorders and regional structural brain changes in adults, but little is known about Val66Met's effect on brain morphology during typical or atypical neurodevelopment. Windows of vulnerability to psychopathology may be associated with the different alleles of the Val66Met polymorphism during childhood and adolescence. Methodology: We investigated the effect of Val66Met on cortical thickness in MRI scans of 718 children and adolescents (6-12 years old) with typical development, and in those meeting DSM criteria for a psychiatric disorder. Results: Val66Met had a significant effect on cortical thickness. Considering the typically developing group, Met carriers presented thicker parietal and occipital lobes and prefrontal cortices compared to Val homozygotes. Met carriers with psychiatric disorders presented thicker medial and lateral temporal cortices than Val homozygotes. Furthermore, a significant genotype x psychiatric diagnosis interaction was found: Met-carriers with a psychiatric diagnosis presented thinner bilateral prefrontal cortices than Val homozygotes. Conclusion: This study provides evidence that Val66Met is associated with cortical maturation in children and adolescents with and without psychiatric disorders. (AU)

• FAPESP's process: 13/08531-5 - High risk cohort study for psychiatric disorders in childhood: 3-year follow-up neuroimaging study
• Grantee: Andrea Parolin Jackowski
• Support Opportunities: Regular Research Grants
• FAPESP's process: 14/07280-1 - Search for genetic markers of risk, progression and response to treatment
• Grantee: Síntia Iole Nogueira Belangero
• Support Opportunities: Regular Research Grants
• FAPESP's process: 14/50917-0 - INCT 2014: developmental psychiatry for children and adolescents
• Grantee: Eurípedes Constantino Miguel Filho
• Support Opportunities: Research Projects - Thematic Grants