Validation of miRNAs and mRNAs-target interactions involved in nervous system deve...
| Full text | |
| Author(s): |
Herkenhoff, Marcos E.
[1]
;
Oliveira, Arthur C.
[1]
;
Nachtigall, Pedro G.
[1]
;
Costa, Juliana M.
[1]
;
Campos, Vinicius F.
[2]
;
Hilsdorf, Alexandre W. S.
[3]
;
Pinhal, Danillo
[1]
Total Authors: 7
|
| Affiliation: | [1] Sao Paulo State Univ, Inst Biosci Botucatu, Dept Genet, Lab Genom & Mol Evolut, Botucatu, SP - Brazil
[2] Univ Fed Pelotas, Technol Dev Ctr, Lab Struct Genom GenEstrut, Grad Program Biotechnol, Pelotas - Brazil
[3] Univ Mogi das Cruzes, Unit Biotechnol, Mogi Das Cruzes - Brazil
Total Affiliations: 3
|
| Document type: | Review article |
| Source: | FRONTIERS IN GENETICS; v. 9, MAR 19 2018. |
| Web of Science Citations: | 6 |
| Abstract | |
In the last decade, several studies have been focused on revealing the microRNA (miRNA) repertoire and determining their functions in farm animals such as poultry, pigs, cattle, and fish. These small non-protein coding RNA molecules (18-25 nucleotides) are capable of controlling gene expression by binding to messenger RNA (mRNA) targets, thus interfering in the final protein output. MiRNAs have been recognized as the main regulators of biological features of economic interest, including body growth, muscle development, fat deposition, and immunology, among other highly valuable traits, in aquatic livestock. Currently, the miRNA repertoire of some farmed fish species has been identified and characterized, bringing insights about miRNA functions and novel perspectives for improving health and productivity. In this review, we summarize the current advances in miRNA research by examining available data on Neotropical and other key species exploited by fisheries and in aquaculture worldwide and discuss how future studies on Neotropical fish could benefit from this knowledge. We also make a horizontal comparison of major results and discuss forefront strategies for miRNA manipulation in aquaculture focusing on forward-looking ideas for forthcoming research. (AU) | |
| FAPESP's process: | 14/03062-0 - Molecular characterization of heterotic hybrid from Red Stirling and Chitralada lines of Nile Tilapia (Oreochromis niloticus) |
| Grantee: | Marcos Edgar Herkenhoff |
| Support type: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 12/15589-7 - Investigation of the composition, function and evolutionary dynamics of microRNAs in fish genomes using RNA-Seq and reverse genetics |
| Grantee: | Danillo Pinhal |
| Support type: | Regular Research Grants |
| FAPESP's process: | 13/06864-7 - Functional analysis of microRNAs in cardiac development of fish species by RNA-Seq and reverse genetics |
| Grantee: | Pedro Gabriel Nachtigall |
| Support type: | Scholarships in Brazil - Doctorate |