| Full text | |
| Author(s): |
Oliveira-Giacomelli, Agatha
[1]
;
Naaldijk, Yahaira
[1]
;
Sarda-Arroyo, Laura
[1]
;
Goncalves, Maria C. B.
[2]
;
Correa-Velloso, Juliana
[1]
;
Pillat, Micheli M.
[1]
;
de Souza, Hellio D. N.
[1]
;
Ulrich, Henning
[1]
Total Authors: 8
|
| Affiliation: | [1] Univ Sao Paulo, Inst Chem, Dept Biochem, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Sch Med, Dept Neurol & Neurosci, Sao Paulo - Brazil
Total Affiliations: 2
|
| Document type: | Review article |
| Source: | FRONTIERS IN PHARMACOLOGY; v. 9, APR 10 2018. |
| Web of Science Citations: | 4 |
| Abstract | |
Since proving adenosine triphosphate (ATP) functions as a neurotransmitter in neuron/glia interactions, the purinergic system has been more intensely studied within the scope of the central nervous system. In neurological disorders with associated motor symptoms, including Parkinson's disease (PD), motor neuron diseases (MND), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Huntington's Disease (HD), restless leg syndrome (RLS), and ataxias, alterations in purinergic receptor expression and activity have been noted, indicating a potential role for this system in disease etiology and progression. In neurodegenerative conditions, neural cell death provokes extensive ATP release and alters calcium signaling through purinergic receptor modulation. Consequently, neuroinflammatory responses, excitotoxicity and apoptosis are directly or indirectly induced. This review analyzes currently available data, which suggests involvement of the purinergic system in neuro-associated motor dysfunctions and underlying mechanisms. Possible targets for pharmacological interventions are also discussed. (AU) | |
| FAPESP's process: | 12/20685-5 - Role of kinins receptor B2 in therapy of Parkinson's Disease in animal model. |
| Grantee: | Héllio Danny Nóbrega de Souza |
| Support type: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 13/25338-4 - Evaluation of the Kallikrein-Kinin System at neurogenesis, proliferation and differentiation level of neuronal precursors from Amyotrophic Lateral Sclerosis patients. |
| Grantee: | Laura Sardá Arroyo |
| Support type: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 12/50880-4 - Stem cells: from basic studies of kinin and purinergic receptor roles towards therapeutical applications |
| Grantee: | Alexander Henning Ulrich |
| Support type: | Research Projects - Thematic Grants |
| FAPESP's process: | 15/14343-2 - Dental pulp derived mesenchymal stem cells and its conditioned medium: a novel therapeutic approach for ALS |
| Grantee: | Yahaira Maria Naaldijk Palma |
| Support type: | Scholarships in Brazil - Post-Doctorate |