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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Involvement of neuronal nitric oxide synthase in cross-sensitization between chronic unpredictable stress and ethanol in adolescent and adult mice

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Author(s):
Santos-Rocha, Jaqueline Borges [1] ; Rae, Mariana [1] ; Aristimunho Teixeira, Ana Maria [1] ; Teixeira, Simone Aparecida [1] ; Munhoz, Carolina Demarchi [1] ; Muscara, Marcelo Nicolas [1] ; Marcourakis, Tania [2] ; Szumlinski, Karen K. [3] ; Camarini, Rosana [1]
Total Authors: 9
Affiliation:
[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Farmacol, BR-05508900 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, BR-05508000 Sao Paulo, SP - Brazil
[3] Univ Calif Santa Barbara, Neurosci Res Inst, Dept Psychol & Brain Sci, Santa Barbara, CA 93106 - USA
Total Affiliations: 3
Document type: Journal article
Source: ALCOHOL; v. 68, p. 71-79, MAY 2018.
Web of Science Citations: 3
Abstract

The peculiar neurochemical profile of the adolescent brain renders it differently susceptible to several stimuli, including stress and/or drug exposure. Among several stress mediators, nitric oxide (NO) has a role in stress responses. We have demonstrated that adolescent mice are less sensitive to ethanol induced sensitization than adult mice. The present study investigated whether chronic unpredictable stress (CUS) induces behavioral sensitization to ethanol in adolescent and adult Swiss mice, and investigated the influence of Ca2+-dependent nitric oxide synthase (NOS) activity in the phenomenon. Adolescent and adult mice were exposed to repeated 1.8 g/kg ethanol or CUS and challenged with saline or ethanol. A neuronal nitric oxide synthase (nNOS) inhibitor, 7-nitroindazole (7NI), was administered along with ethanol and CUS to test its effects on behavioral sensitization. Both adolescent and adult mice displayed cross-sensitization between CUS and ethanol in adult mice, with adolescents showing a lower degree of sensitization than adults. nNOS inhibition by 7NI reduced both ethanol sensitization and cross sensitization. All age differences in the Ca2+-dependent NOS activity in the hippocampus and prefrontal cortex were in the direction of greater activity in adults than in adolescents. Adolescents showed lower sensitivity to cross-sensitization between CUS and ethanol, and the nitric oxide (NO) system seems to have a pivotal role in ethanol-induced behavioral sensitization and cross-sensitization in both adolescent and adult mice. (C) 2017 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 15/02397-0 - Study of environmental enrichment inducing a protective phenotype of behaviors that assess addictive features in mice
Grantee:Rosana Camarini
Support Opportunities: Regular Research Grants
FAPESP's process: 12/50207-8 - Effects and neurobiological mechanisms of environmental manipulations on ethanol and nicotine induced behavioural effects: involvement of the stress circuitry
Grantee:Rosana Camarini
Support Opportunities: Regular Research Grants