Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Possible Breathing Influences on the Control of Arterial Pressure After Sino-aortic Denervation in Rats

Full text
Amorim, Mateus R. [1] ; Souza, George Miguel P. R. [1] ; Machado, Benedito H. [1]
Total Authors: 3
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Physiol, BR-14049900 Ribeirao Preto, SP - Brazil
Total Affiliations: 1
Document type: Review article
Web of Science Citations: 1

Purpose of Review Surgical removal of the baroreceptor afferents {[}sino-aortic denervation (SAD)] leads to a lack of inhibitory feedback to sympathetic outflow, which in turn is expected to result in a large increase in mean arterial pressure (MAP). However, few days after surgery, the sympathetic nerve activity (SNA) and MAP of SAD rats return to a range similar to that observed in control rats. In this review, we present experimental evidence suggesting that breathing contributes to control of SNA and MAP following SAD. The purpose of this review was to discuss studies exploring SNA and MAP regulation in SAD rats, highlighting the possible role of breathing in the neural mechanisms of this modulation of SNA. Recent Findings Recent studies show that baroreceptor afferent stimulation or removal (SAD) results in changes in the respiratory pattern. Summary Changes in the neural respiratory network and in the respiratory pattern must be considered among mechanisms involved in the modulation of the MAP after SAD. (AU)

FAPESP's process: 13/06077-5 - Changes in the neural networks involved with the generation and control of sympathetic and respiratory activities in different experimental models of hypoxia
Grantee:Benedito Honorio Machado
Support type: Research Projects - Thematic Grants
FAPESP's process: 13/15195-1 - Electrophysiological characterization of respiratory and presympathetic neurons in the rostral ventrolateral medulla after sinoaortic denervation in rats
Grantee:Mateus Ramos Amorim
Support type: Scholarships in Brazil - Doctorate