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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Markers of nutritional status and mortality in older adults: The role of anemia and hypoalbuminemia

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Corona, Ligiana Pires [1] ; de Oliveira Duarte, Yeda Aparecida [2] ; Lebrao, Maria Lucia [3]
Total Authors: 3
[1] Univ Estadual Campinas, Sch Appl Sci, R Pedro Zaccaria 1300, BR-13484350 Limeira, SP - Brazil
[2] Univ Sao Paulo, Sch Nursing, Dept Med Surg Nursing, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Sch Publ Hlth, Dept Epidemiol, Ave Doutor Arnaldo 715, 1 Andar, BR-01246904 Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Geriatrics & Gerontology International; v. 18, n. 1, p. 177-182, JAN 2018.
Web of Science Citations: 5

Aim: The aim of the present study was to analyze the impact of anemia and hypoalbuminemia on mortality in a 5-year period. Methods: This was longitudinal population-based observational survey part of the Saude, Bem-Estar e Envelhecimento study (Health, Well-being and Aging), carried out with 1256 older adults from the third wave of the cohort, followed for 5 years, when they were contacted for the fourth wave, in Sao Paulo, Brazil. Anemia was defined when hemoglobin was < 12 g/dL for women and < 13 g/dL for men, and hypoalbuminemia when serum albumin was < 3.5 g/dL. Survival functions were estimated according to nutritional status in four groups: (i) without nutritional alteration; (ii) anemia only; (iii) hypoalbuminemia only; and (iv) anemia and hypoalbuminemia. Hazard ratios were calculated, following the Cox proportional hazards model, controlling for baseline covariates. All analyses considered sample weights, and were carried out using the Stata 12. Results: After the 5-year period, 12.3% of the participants died, and 8.2% were lost to follow up. Those who died had lower hemoglobin and albumin concentrations (13.4 g/dL and 3.7 g/dL) compared with survivors (14.3d/dL and 3.9 g/dL; P < 0.001). The crude death rate was 27.6/1000 person-years for participants in group i, 124.3 in group ii, 116.0 in group iii and 222.8 in group iv (P < 0.001). In the final Cox models, group 2 and 3 had a similar effect (hazard ratio 2.23, P = 0.020; 2.53, P = 0.005; respectively) and group 4 had a higher risk (hazard ratio 3.36; P = 0.004). Conclusions: Anemia and hypoalbuminemia are importantmarkers for death in older adults, and have an additive effect on mortality. Because they are common and cost-effective biomarkers, their use should be encouraged in geriatric evaluation for all health professionals and in population settings, such as primary care. Geriatr (AU)

FAPESP's process: 14/23587-0 - Anemia and nutritional status in the evolution of functionality and survival in older adults
Grantee:Ligiana Pires Corona
Support type: Regular Research Grants
FAPESP's process: 09/53778-3 - SABE Study –2010: Health, well-being and aging
Grantee:Maria Lúcia Lebrão
Support type: Research Projects - Thematic Grants