Diagnosing Sarcopenia in Male Patients With Cirrhosis by Dual-Energy X-Ray Absorptiometry Estimates of Appendicular Skeletal Muscle Mass

Author(s):Show less -

Belarmino, Giliane ^[1] ; Gonzalez, Maria Cristina ^{[2, 3]} ; Sala, Priscila ^[1] ; Torrinhas, Raquel Susana ^[1] ; Andraus, Wellington ^[1] ; Carneiro D'Albuquerque, Luiz Augusto ^[1] ; Pereira, Rosa Maria R. ^[4] ; Caparbo, Valeria F. ^[4] ; Ferrioli, Eduardo ^[5] ; Pfrimer, Karina ^[5] ; Damiani, Lucas ^[6] ; Heymsfield, Steven B. ^[3] ; Waitzberg, Dan L. ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Med, Surg Div, Dept Gastroenterol LIM 35, Sao Paulo - Brazil

^[2] Univ Catolica Pelotas, Postgrad Program Hlth & Behav, Pelotas, RS - Brazil

^[3] Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 - USA

^[4] Univ Sao Paulo, Fac Med, Rheumatol Div, Lab Bone Metab, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Med Clin, Sao Paulo - Brazil

^[6] Hosp Coracao Sao Paulo, Res Inst, Sao Paulo - Brazil

• Document type: Journal article
• Source: Journal of Parenteral and Enteral Nutrition; v. 42, n. 1, p. 24-36, JAN 2018.
• Web of Science Citations: 8

Abstract

Background: Ascites in cirrhotic patients interfere with accurate assessment of skeletal muscle when diagnosing sarcopenia. We hypothesized measurement of appendicular skeletal muscle index (ASMI) with dual-energy x-ray absorptiometry (DXA) improves the diagnosis of sarcopenia in cirrhotic patients as ASMI does not include the fluid-filled abdominal compartment. Objective: To evaluate if ASMI is influenced by ascites, lower limb edema (LLE) and predicts mortality alone or combined with handgrip strength (HGS) in cirrhotic patients. Design: ASMI, HGS, and 36-month mortality were obtained in 144 men with cirrhosis. ASMI was compared before and after paracentesis in 20 men with ascites and to results from 20 matched controls. The prognostic value of ASMI alone and with HGS was tested in a survival. Survival probabilities were obtained for sarcopenia diagnosed by standard ASMI and HGS European Working Group on Sarcopenia in Older People (EWGSOP) cutoffs and a new cutoff calculated from our ASMI + HGS tertiles. Results: ASMI did not change after paracentesis, was lower in patients than in controls (P < .001), and was not influenced by LLE (D = 0.30 kg/m2, P = .068; R-2 = 2.40%). Mortality was influenced by ASMI and HGS (P-interaction = 0.028). Sarcopenia diagnosed by EWGSOP was also diagnosed by our new cutoff; both predicted mortality with the latter more sensitive for mortality risk prediction (P = .011). Conclusions: DXA-measured ASMI is not influenced by ascites or LLE in cirrhotic patients; can diagnose low skeletal muscle/sarcopenia; and predicts mortality, particularly when combined with HGS. (AU)

• FAPESP's process: 12/15677-3 - Development of bioelectrical impedance analysis prediction equations for body composition with the use of a multicomponent model in cirrhotic patients
• Grantee: Giliane Belarmino
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 11/13243-3 - Development of bioelectrical impedance analysis prediction equations for body composition with the use of a multicomponent model in cirrhotic patients
• Grantee: Dan Linetzky Waitzberg
• Support Opportunities: Regular Research Grants