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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of high-impact exercise on the physical properties of bones of ovariectomized rats fed to a high-protein diet

Full text
Author(s):
Shimano, R. C. [1] ; Yanagihara, G. R. [1] ; Macedo, A. P. [1] ; Yamanaka, J. S. [1] ; Shimano, A. C. [1] ; Tavares, J. M. R. S. [2] ; Issa, J. P. M. [3]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Biomecan Med & Reabil Aparelho, Sao Paulo - Brazil
[2] Univ Porto, Fac Engn, Dept Engn Mecan, Inst Ciencia & Inovacao Engn Mecan & Engn Ind, Porto - Portugal
[3] Univ Sao Paulo, Fac Odontol Ribeirao Preto, Dept Morfol Fisiol & Patol Basica, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS; v. 28, n. 5, p. 1523-1531, MAY 2018.
Web of Science Citations: 1
Abstract

The aim of this study was to evaluate the effects of high-impact physical exercise as a prophylactic and therapeutic means in osteopenic bones of rats submitted to ovariectomy and protein diet intake. A total of 64 Wistar rats were divided into eight groups (n=8 each), being: OVX, ovx, standard diet and sedentary; OVXE, ovx, standard diet and jump; OVXP, ovx, high-protein diet and sedentary; and OVXEP, ovx, high-protein diet and jump; SH, sham, standard diet and sedentary; SHE, sham, standard diet and jump; SHP, sham, high-protein diet and sedentary; and SHEP, sham, high-protein diet and jump. OVX surgery consists of ovariectomy, and sham was the control surgery. The jumping protocol consisted of 20 jumps/day, 5days/week. The bone structure was evaluated by densitometry, mechanical tests, histomorphometric, and immunohistochemical analyses. A high-protein diet resulted in increased bone mineral density (P=.049), but decreased maximal load (P=.026) and bone volume fraction (P=.023). The benefits of physical exercise were demonstrated by higher values of the maximal load in the trained groups compared to the sedentary groups (P<.001). The sham groups had decreased immunostaining of osteocalcin (P=.004) and osteopontin (P=.010) compared to ovx groups. However, the high-protein diet (P=.005) and jump exercise (P=.017) resulted in lower immunostaining of osteopontin compared to the standard diet and sedentary groups, respectively. In this experimental model, it was concluded that ovariectomy and a high-fat diet can negatively affect bone tissue and the high-impact exercise was not enough to suppress the deleterious effects caused by the protein diet and ovariectomy. (AU)

FAPESP's process: 15/16194-4 - The role of MMP-9 in the pathogenesis of osteoporosis in animal models of atherosclerosis
Grantee:João Paulo Mardegan Issa
Support Opportunities: Regular Research Grants
FAPESP's process: 14/10733-8 - Tissue and biomechanics analysis of bones of rats fed high-fat diet: experimental study of the relationship between fat mass and bone loss
Grantee:Antônio Carlos Shimano
Support Opportunities: Regular Research Grants
FAPESP's process: 14/25879-8 - Tissue and biomechanical analysis of bones of ovariectomized rats fed a high-fat diet
Grantee:Gabriela Rezende Yanagihara
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 15/26142-1 - Image Processing and Analysis obtained by Scanning Electron Microscopy of bone of female obese and eutrophic rats
Grantee:Gabriela Rezende Yanagihara
Support Opportunities: Scholarships abroad - Research Internship - Doctorate