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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Prospective and Randomized Evaluation of ChronOS and Bio-Oss in Human Maxillary Sinuses: Histomorphometric and Immunohistochemical Assignment for Runx2, Vascular Endothelial Growth Factor, and Osteocalcin

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Bonardi, Joao Paulo [1] ; Pereira, Rodrigo dos Santos [1] ; Jorge Boos Lima, Fernanda Brasil Daura [2] ; Faverani, Leonardo Perez [1] ; Griza, Geraldo Luiz [1] ; Okamoto, Roberta [1] ; Hochuli-Vieira, Eduardo [1]
Total Authors: 7
[1] Univ Estadual Paulista, Surg & Integrated Clin Dept, Sao Paulo, SP - Brazil
[2] Univ Fed Minas Gerais, Dept Clin Pathol & Surg, Belo Horizonte, MG - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY; v. 76, n. 2, p. 325-335, FEB 2018.
Web of Science Citations: 2

Purpose: The aim of this study was to compare ChronOS (beta-tricalcium phosphate), Bio-Oss, and their addition to an autogenous bone graft in a 1: 1 ratio in human maxillary sinus bone augmentation. Materials and Methods: Thirty maxillary sinuses were divided in 5 groups: group 1 included 6 maxillary sinuses grafted with autogenous bone graft alone; group 2 included 6 maxillary sinuses grafted with ChronOS; group 3 included 6 maxillary sinuses grafted with ChronOS and autogenous bone graft in a 1: 1 ratio; group 4 included 6 maxillary sinuses grafted with Bio-Oss; and group 5 included 6 maxillary sinuses grafted with Bio-Oss and autogenous bone graft in a 1: 1 ratio. The number of samples for each group was determined by the statistical power test. Results: The median areas of new bone formation in groups 1, 2, 3, 4, and 5 were 121,917.0, 83,787.0, 99,295.0, 65,717.0, and 56,230.0 mu m(2), respectively. Statistically significant differences were found between groups 3 and 5, groups 1 and 4, and groups 1 and 5 (P <.05). The median areas of remaining biomaterial were 2,900.5, 5,291.0, 2,662.0, 56,258.5, and 64,753.5 mu m(2) in groups 1, 2, 3, 4 and 5, respectively. Statistically significant differences occurred between groups 1 and 5, groups 3 and 5, and groups 2 and 5 (P <.05). Areas of connective tissue were 67,829.0 +/- 22,984.6 mu m(2) in group 1, 97,445.9 +/- 18,983.3 mu m(2) in group 2, 88,256.0 +/- 21,820.5 mu m(2) in group 3, 65,501.8 +/- 6,297.6 in group 4, and 70,203.2 +/- 13,421.3 mu m(2) in group 5. Conclusions: ChronOS combined with autogenous bone graft presented a behavior similar to that of autogenous bone graft alone. However, the groups treated with Bio-Oss showed immuno-labeling results indicating maturation of grafted bone. (C) 2017 American Association of Oral and Maxillofacial Surgeons (AU)

FAPESP's process: 12/08455-4 - Tomografic, Histologic, Histometric and imunohistochemistry analyses of Beta tricalcium Phosphate and Autogenous Bone Mixture in Sinus Floor Augmentation.
Grantee:Rodrigo dos Santos Pereira
Support type: Scholarships in Brazil - Master
FAPESP's process: 12/10028-7 - Comparative study of the repair process using autogenous bone and beta-tricalcium phosphate in human sinus floor augmentation: tomographical, histological, histometrical and imunohistochemical evaluation
Grantee:Eduardo Hochuli Vieira
Support type: Regular Research Grants