Prospective and Randomized Evaluation of ChronOS and Bio-Oss in Human Maxillary Sinuses: Histomorphometric and Immunohistochemical Assignment for Runx2, Vascular Endothelial Growth Factor, and Osteocalcin

Author(s)

Bonardi, Joao Paulo ^[1] ; Pereira, Rodrigo dos Santos ^[1] ; Jorge Boos Lima, Fernanda Brasil Daura ^[2] ; Faverani, Leonardo Perez ^[1] ; Griza, Geraldo Luiz ^[1] ; Okamoto, Roberta ^[1] ; Hochuli-Vieira, Eduardo ^[1]

Affiliation

^[1] Univ Estadual Paulista, Surg & Integrated Clin Dept, Sao Paulo, SP - Brazil

^[2] Univ Fed Minas Gerais, Dept Clin Pathol & Surg, Belo Horizonte, MG - Brazil

• Document type: Journal article
• Source: JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY; v. 76, n. 2, p. 325-335, FEB 2018.
• Web of Science Citations: 2

Abstract

Purpose: The aim of this study was to compare ChronOS (beta-tricalcium phosphate), Bio-Oss, and their addition to an autogenous bone graft in a 1: 1 ratio in human maxillary sinus bone augmentation. Materials and Methods: Thirty maxillary sinuses were divided in 5 groups: group 1 included 6 maxillary sinuses grafted with autogenous bone graft alone; group 2 included 6 maxillary sinuses grafted with ChronOS; group 3 included 6 maxillary sinuses grafted with ChronOS and autogenous bone graft in a 1: 1 ratio; group 4 included 6 maxillary sinuses grafted with Bio-Oss; and group 5 included 6 maxillary sinuses grafted with Bio-Oss and autogenous bone graft in a 1: 1 ratio. The number of samples for each group was determined by the statistical power test. Results: The median areas of new bone formation in groups 1, 2, 3, 4, and 5 were 121,917.0, 83,787.0, 99,295.0, 65,717.0, and 56,230.0 mu m(2), respectively. Statistically significant differences were found between groups 3 and 5, groups 1 and 4, and groups 1 and 5 (P <.05). The median areas of remaining biomaterial were 2,900.5, 5,291.0, 2,662.0, 56,258.5, and 64,753.5 mu m(2) in groups 1, 2, 3, 4 and 5, respectively. Statistically significant differences occurred between groups 1 and 5, groups 3 and 5, and groups 2 and 5 (P <.05). Areas of connective tissue were 67,829.0 +/- 22,984.6 mu m(2) in group 1, 97,445.9 +/- 18,983.3 mu m(2) in group 2, 88,256.0 +/- 21,820.5 mu m(2) in group 3, 65,501.8 +/- 6,297.6 in group 4, and 70,203.2 +/- 13,421.3 mu m(2) in group 5. Conclusions: ChronOS combined with autogenous bone graft presented a behavior similar to that of autogenous bone graft alone. However, the groups treated with Bio-Oss showed immuno-labeling results indicating maturation of grafted bone. (C) 2017 American Association of Oral and Maxillofacial Surgeons (AU)

• FAPESP's process: 12/10028-7 - Comparative study of the repair process using autogenous bone and beta-tricalcium phosphate in human sinus floor augmentation: tomographical, histological, histometrical and imunohistochemical evaluation
• Grantee: Eduardo Hochuli Vieira
• Support Opportunities: Regular Research Grants
• FAPESP's process: 12/08455-4 - Tomografic, Histologic, Histometric and imunohistochemistry analyses of beta tricalcium phosphate and autogenous bone mixture in sinus floor augmentation
• Grantee: Rodrigo dos Santos Pereira
• Support Opportunities: Scholarships in Brazil - Master