Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Subtle Alterations in Spatial Memory Induced by Amyloid Peptides Infusion in Rats

Full text
Author(s):
Macedo, Priscila Tavares [1, 2] ; Aquino, Antonio C. Q. [2] ; Meurer, Ywlliane S. R. [2, 3] ; Brandao, Luiz E. M. [2] ; Campelo, Clarissa L. C. [2] ; Lima, Ramon H. [2] ; Costa, Marcos R. [1] ; Ribeiro, Alessandra M. [4] ; Silva, Regina H. [3]
Total Authors: 9
Affiliation:
[1] Univ Fed Rio Grande do Norte, Brain Inst, Natal, RN - Brazil
[2] Univ Fed Rio Grande do Norte, Physiol Dept, Memory Studies Lab, Natal, RN - Brazil
[3] Univ Fed Sao Paulo, Pharmacol Dept, Behav Neurosci Lab, Sao Paulo - Brazil
[4] Univ Fed Sao Paulo, Dept Biosci, Lab Neurosci & Bioprospecting Nat Prod, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: FRONTIERS IN AGING NEUROSCIENCE; v. 10, JAN 30 2018.
Web of Science Citations: 0
Abstract

The cause of Alzheimer's disease (AD) remains uncertain. The accumulation of amyloid peptides (A beta) is the main pathophysiological hallmark of the disease. Spatial deficit is an important initial sign of AD, while other types of memory impairments that appear in later stages. The Barnes maze allows the detection of subtle alterations in spatial search by the analysis of use of different strategies. Previous findings showed a general performance deficit in this task following long-term (35 days) infusion of A beta, which corresponds to the moderate or severe impairments of the disease. In the present study, we evaluated the effects of a low-dose 15-day long treatment with A beta peptides on spatial and non-spatial strategies of rats tested in the Barnes maze. A beta peptides (0.5 mu L/site/day; 30 pmoL solution of A beta 1-40:A beta 1-42 10: 1) or saline were bilaterally infused into the CA1 (on the first treatment day) and intraventricularly (on the following 15 days) in 6-month-old Wistar male rats. A beta infusion induced a deficit in the performance (increased latency and distance traveled to reach the target compared to saline group). In addition, a significant association between treatment and search strategy in the retrieval trial was found: A beta group preferred the non-spatial search strategy, while saline group preferred the spatial search. In conclusion, the protocol of A beta infusion used here induced a subtle cognitive deficit that was specific to spatial aspects. Indeed, animals under A beta treatment still showed retrieval, but using non-spatial strategies. We suggest that this approach is potentially useful to the study of the initial memory deficits in early AD. (AU)

FAPESP's process: 15/12308-5 - Analysis of the mechanisms related to differences in the progression of motor deficits between Wistar and SHR (spontaneously hypertensive rat) rats submitted to pharmacological models of Parkinson's Disease
Grantee:Anderson Henrique França Figueredo Leão
Support Opportunities: Scholarships in Brazil - Post-Doctoral