| Full text | |
| Author(s): |
Ribeiro, Fernanda V.
[1]
;
Casati, Marcio Z.
[1]
;
Casarin, Renato C.
[1]
;
Correa, Monica G.
[1]
;
Cirano, Fabiano R.
[1]
;
Negri, Brenno M.
[1]
;
Pimentel, Suzana P.
[1]
Total Authors: 7
|
| Affiliation: | [1] Univ Paulista, Sch Dent, Dent Res Div, Sao Paulo, SP - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | Journal of Periodontology; v. 89, n. 2, p. 203-212, FEB 2018. |
| Web of Science Citations: | 6 |
| Abstract | |
BackgroundThis study evaluated the influence of a triclosan-containing toothpaste in the profile of osteo-immunoinflammatory mediators in peri-implant crevicular fluid (PICF) and in clinical parameters during progression of peri-implant mucositis. MethodsTwenty-two clinically healthy patients with an implant-supported single-unit crown were enrolled in this double-blind, randomized, crossover study carried out in two phases of 21 days each. During an experimental 3-week period of undisturbed plaque accumulation in the implants, patients were randomly assigned to use three times/day: triclosan (n=11), triclosan/copolymer/fluoride toothpaste; or placebo (n=11), fluoride toothpaste. After a professional prophylaxis, a washout period of 30 days was established. Clinical parameters and 15 osteo-immunoinflammatory mediators in the PICF were evaluated at baseline and at 3, 7, 14, and 21 days. ResultsBoth groups showed increase in plaque index at implant sites from the 3rd until the 21st day (P<0.05). Only triclosan treatment was able to avoid an increase in bleeding on probing (BOP) throughout the follow-ups (P>0.05), whereas a significant intensification in BOP was observed from the 14th day in the placebo-treated sites (P<0.05). Lower interleukin (IL)-10 concentrations were detected in the placebo group at the 21st day when compared with triclosan-treated implant sites (P<0.05). IL-10 levels were reduced and IL-1 concentrations were increased at 21 days when compared with baseline only in placebo-treated sites (P<0.05). Osteoprotegerin levels significantly increased from the 14th until the 21st day only in triclosan-treated sites (P<0.05). ConclusionTriclosan-containing toothpaste controls clinical inflammation and interferes positively in the profile of osteo-immunoinflammatory mediators during progression of experimental peri-implant mucositis. (AU) | |