Predictors of Obstructive Sleep Apnea in Consecutive Patients with Metabolic Syndrome

Author(s):Show less -

Pedrosa, Rodrigo P. ^[1] ; Maki-Nunes, Cristiane ^[2] ; Midlej-Brito, Thiago ^[2] ; Lopes, Heno F. ^[2] ; Freitas, Lunara S. ^[2] ; Trombetta, Ivani C. ^[2] ; Toschi-Dias, Edgar ^[2] ; Alves, Maria Janieire N. N. ^[2] ; Fraga, Raffael F. ^[2] ; Rondon, Maria U. ^[3] ; Negrao, Carlos E. ^{[2, 3]} ; Bortolotto, Luiz A. ^[2] ; Lorenzi-Filho, Geraldo ^[2] ; Drager, Luciano F. ^[2]

Affiliation

^[1] Univ Pernambuco, Sleep & Heart Lab, Pronto Socorro Cardiol Pernambuco, Recife, PE - Brazil

^[2] Univ Sao Paulo, Heart Inst InCor, Hypertens Unit, Sch Med, Ave Dr Eneas Carvalho de Aguiar 44, BR-05403904 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Phys Educ & Sports, Sch Med, Sao Paulo - Brazil

• Document type: Journal article
• Source: METABOLIC SYNDROME AND RELATED DISORDERS; v. 16, n. 1, p. 2-5, FEB 2018.
• Web of Science Citations: 2

Abstract

Background: Recent evidence suggests that obstructive sleep apnea (OSA) is common in patients with metabolic syndrome (MetS) and may contribute to metabolic deregulation, inflammation, and atherosclerosis in these patients. In clinical practice, however, OSA is frequently underdiagnosed. We sought to investigate the clinical predictors of OSA in patients with MetS. Methods: We studied consecutive patients newly diagnosed with MetS (Adult Treatment Panel-III). All participants underwent clinical evaluation, standard polysomnography, and laboratory measurements. We performed a logistic regression model, including the following variables: gender, age >50 years, neck and waist circumferences, hypertension, diabetes, body mass index (BMI) >30kg/m(2), high risk for OSA by Berlin questionnaire, presence of excessive daytime somnolence (Epworth Sleepiness Scale), abnormal serum glucose, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol. Results: We studied 197 patients (60% men; age: 4910 years; BMI: 32.9 +/- 5.1kg/m(2)). OSA (defined by an apnea-hypopnea index 15 events per hour) was diagnosed in 117 patients {[}59%; 95% confidence interval (CI): 52-66]. In multivariate analysis, male gender {[}odds ratio (OR): 3.28; 95% CI: 1.68-6.41; P<0.01], abnormal glucose levels (OR: 3.01; 95% CI: 1.50-6.03; P<0.01), excessive daytime sleepiness (OR: 2.38; 95% CI: 1.13-5.04; P=0.02), and high risk for OSA by Berlin questionnaire (OR: 4.33; 95% CI: 2.06-9.11; P<0.001) were independently associated with OSA. Conclusions: Simple clinical and metabolic characteristics may help to improve the underdiagnosis of OSA in patients with MetS. (AU)

• FAPESP's process: 12/02953-2 - Impact of obstructive sleep apnea and sleep duration on the progression of cardiovascular diseases
• Grantee: Luciano Ferreira Drager
• Support Opportunities: Research Grants - Young Investigators Grants