|
Full text
|
Author(s):
Show less - |
Furigo, Isadora C.
[1]
;
Melo, Helen M.
[2]
;
Lyra e Silva, Natalia M.
[2]
;
Ramos-Lobo, Angela M.
[1]
;
Teixeira, Pryscila D. S.
[1]
;
Buonfiglio, Daniella C.
[1]
;
Wasinski, Frederick
[1]
;
Lima, Eliana R.
[3]
;
Higuti, Eliza
[3]
;
Peroni, Cibele N.
[3]
;
Bartolini, Paolo
[3]
;
Soares, Carlos R. J.
[3]
;
Metzger, Martin
[1]
;
de Felice, Fernanda G.
[2, 4]
;
Donato, Jr., Jose
[1]
Total Authors: 15
|
| Affiliation: | [1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Ave Prof Lineu Prestes 1524, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Fed Rio de Janeiro, Inst Med Biochem Leopoldo Meis, BR-21944590 Rio De Janeiro, RJ - Brazil
[3] IPEN CNEN, Ctr Biotechnol, BR-05508900 Sao Paulo, SP - Brazil
[4] Queens Univ, Dept Biomed & Mol Sci, Ctr Neurosci Studies, Kingston, ON K7L 3N6 - Canada
Total Affiliations: 4
|
| Document type: |
Journal article
|
| Source: |
Brain Structure & Function;
v. 223,
n. 5,
p. 2229-2241,
JUN 2018.
|
| Web of Science Citations: |
9
|
| Abstract |
The signal transducer and activator of transcription 5 (STAT5) is a transcription factor recruited by numerous cytokines. STAT5 is important for several physiological functions, including body and tissue growth, mammary gland development, immune system and lipid metabolism. However, the role of STAT5 signaling for brain functions is still poorly investigated, especially regarding cognitive aspects. Therefore, the objective of the present study was to investigate whether brain STAT5 signaling modulates learning and memory formation. For this purpose, brain-specific STAT5 knockout (STAT5 KO) mice were studied in well-established memory tests. Initially, we confirmed a robust reduction in STAT5a and STAT5b mRNA levels in different brain structures of STAT5 KO mice. STAT5 KO mice showed no significant alterations in metabolism, growth, somatotropic axis and spontaneous locomotor activity. In contrast, brain-specific STAT5 ablation impaired learning and memory formation in the novel object recognition, Barnes maze and contextual fear conditioning tests. To unravel possible mechanisms that might underlie the memory deficits of STAT5 KO mice, we assessed neurogenesis in the hippocampus, but no significant differences were observed between groups. On the other hand, reduced insulin-like growth factor-1 (IGF-1) mRNA expression was found in the hippocampus and hypothalamus of STAT5 KO mice. These findings collectively indicate that brain STAT5 signaling is required to attain normal learning and memory. Therefore, STAT5 is an important downstream cellular mechanism shared by several cytokines to regulate cognitive functions. (AU) |
|
| FAPESP's process: |
12/02388-3 - Topography and transmitter phenotype of the projections between the lateral habenula, the rostromedial tegmental nucleus and the dorsal raphe nucleus in the rat
|
| Grantee: | Martin Andreas Metzger |
| Support type: |
Regular Research Grants
|
|
|
| FAPESP's process: |
16/20897-3 - Role of orexin neurons as mediators of the central effects induced by growth hormone
|
| Grantee: | Frederick Wasinski |
| Support type: |
Scholarships in Brazil - Post-Doctorate
|
|
|
| FAPESP's process: |
14/11752-6 - Study of leptin functions during intrauterine and childhood stages in mice
|
| Grantee: | Angela Maria Ramos Lobo |
| Support type: |
Scholarships in Brazil - Doctorate
|
|
|
| FAPESP's process: |
15/10992-6 - Investigation of metabolic programming through different approaches
|
| Grantee: | Jose Donato Junior |
| Support type: |
Regular Research Grants
|
|
|
| FAPESP's process: |
12/24345-4 - Evaluation of the potential of prolactin antagonists to the treatment of obesity and Diabetes mellitus 2
|
| Grantee: | Carlos Roberto Jorge Soares |
| Support type: |
Regular Research Grants
|
|
|
| FAPESP's process: |
17/02983-2 - The role of growth hormone in the brain: relevance for neural functions and in disease
|
| Grantee: | Jose Donato Junior |
| Support type: |
Research Projects - Thematic Grants
|
|
|
| FAPESP's process: |
16/09679-4 - Central effects of growth hormone on energetic metabolism and glicemic control
|
| Grantee: | Isadora Clivatti Furigo |
| Support type: |
Scholarships in Brazil - Post-Doctorate
|
|