Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Simultaneous determination of dopamine and cysteamine by flow injection with multiple pulse amperometric detection using a boron-doped diamond electrode

Full text
Author(s):
Wong, Ademar [1] ; Santos, Anderson Martin [1] ; Fatibello-Filho, Orlando [1]
Total Authors: 3
Affiliation:
[1] Univ Fed Sao Carlos, Dept Chem, POB 676, BR-13560970 Sao Carlos, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: DIAMOND AND RELATED MATERIALS; v. 85, p. 68-73, MAY 2018.
Web of Science Citations: 6
Abstract

A flow injection analysis (FIA) system with multiple pulse amperometric (MPA) detection was proposed for the simultaneous determination of dopamine (DOP) and cysteamine (CYS) using a cathodically pre-treated boron-doped diamond electrode (CPT-BDD). The electrochemical behaviors of DOP and CYS were evaluated by cyclic voltammetry in a potential range from 0 to 1.7 V at a scan rate of 0.05 V s(-1) using 0.05 mol L-1 H2SO4 as supporting electrolyte. Two oxidation peaks were observed during anodic potential scanning, at potentials of 0.8 V (DOP) and 1.6 V (CYS). Under optimized experimental conditions, such as potentials E-1 = + 0.8 V 100 ms(-1) (pulse potential at which DOP was oxidized) and E-2 = + 1.6 V 200 ms(-1) (pulse potential at which both analytes were oxidized), the analytical curves were linear in the concentration ranges from 5.0 x 10(-7) to 1.3 x 10(-4) mol L-1 for DOP and from 5.0 x 10(-7) to 1.5 x 10(-4) mol for CYS, with detection limits of 1.1 x 10(-8) and 1.3 x 10(-8) mol L-1, respectively. The BDD sensor showed good sensitivity, stability and repeatability (analytical frequency of 165 determinations per hour), and no interference in the electrochemical determination of these analytes in the presence of other compounds. The proposed method was successfully applied using the FIA-MPA method in river water and serum samples, with recoveries close to 100%. (AU)

FAPESP's process: 11/13312-5 - Development and application of carbon and nanoparticles base electrodes for the determination of species of interest in different matrices
Grantee:Orlando Fatibello Filho
Support type: Regular Research Grants