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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Ion-releasing dental restorative composites containing functionalized brushite nanoparticles for improved mechanical strength

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Author(s):
Rodrigues, Marcela C. [1] ; Chiari, Marina D. S. [1] ; Alania, Yvette [1] ; Natale, Livia C. [1] ; Arana-Chavez, Victor E. [1] ; Meier, Marcia M. [2] ; Fadel, Victoria S. [2] ; Vichi, Flavio M. [3] ; Hewer, Thiago L. R. [4] ; Braga, Roberto R. [1]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Dept Biomat & Oral Biol, Sch Dent, Sao Paulo - Brazil
[2] Santa Catarina State Univ, Dept Chem, Florianopolis, SC - Brazil
[3] Univ Sao Paulo, Inst Chem, Dept Fundamental Chem, Sao Paulo - Brazil
[4] Univ Sao Paulo, Dept Chem Engn, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Dental Materials; v. 34, n. 5, p. 746-755, MAY 2018.
Web of Science Citations: 2
Abstract

Objectives. This study describes the synthesis of brushite nanoparticles (CaHPO4 center dot 2H(2)O) functionalized with triethylene glycol dimethacrylate (TEGDMA) and their application in dental restorative composites with remineralizing capabilities. Methods. Nanoparticles were synthesized, with TEGDMA being added to one of the precursor solutions at three different molar ratios (0:1, 0.5:1 and 1:1, in relation to the ammonium phosphate precursor). Then, they were added (10 vol%) to a photocurable dimethacrylate matrix containing 50 vol% of reinforcing glass particles. The resulting composites were tested for degree of conversion, biaxial flexural strength and elastic modulus (after 24 h and 28 days in water), and ion release (over a 28-day period). Commercial composites (one microhybrid and one microfilled) were tested as controls. Results. The final TEGDMA content in the functionalizing layer was modulated by the molar ratio added to the precursor solution. Functionalization reduced nanoparticle size, but did not reduce agglomeration. Improved mechanical properties were found for the composite containing nanoparticles with higher TEGDMA level in comparison to the composite containing non-functionalized nanoparticles or those with a low TEGDMA level. All brushite composites presented statistically significant reductions in strength after 28 days in water, but only the material with high-TEGDMA nanoparticles retained strength similar to the microhybrid commercial control. Overall, ion release was not affected by functionalization and presented steady levels for 28 days. Significance. Though agglomeration was not reduced by functionalization, the improvement in the matrix-nanoparticle interface allowed for a stronger material, without compromising its remineralizing potential. (C) 2018 The Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 12/25253-6 - Effect of the addition of amorphous calcium phosphate (ACP) over the physicochemical properties of experimental composites
Grantee:Marina Damasceno e Souza de Carvalho Chiari
Support Opportunities: Scholarships in Brazil - Scientific Initiation