The role of the addition of TiO2 nanostructures functionalized in modified resin composites containing thiouretane

• Grant number: 20/02960-5
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): October 01, 2020
• Effective date (End): May 21, 2024
• Field of knowledge: Health Sciences - Dentistry - Dental Materials
• Principal Investigator: Adilson Yoshio Furuse
• Grantee: Genine Moreira de Freitas Guimarães
• Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil
• Associated scholarship(s): 20/15417-8 - Influence of the organic matrix behavior of thio-urethane-based resin composites containing functionalized TiO2 nanostructures, BE.EP.DR

Abstract

The aim of this work is to evaluate the effect of different TiO2 nanotubes and nanoparticles, functionalized and added in experimental resin composites using thiourethane, in order to evaluate their mechanical and biological properties of the material. TiO2 nanostructures will be synthesized and functionalized with 3-Trimethoxysilyl-Propeil-Methacrylate (TMSPM) or Tiouretano-silane (TiOU). Characterizations such as EDS, FTIR and TGA will be performed to confirm the effectiveness of the features. Experimental composite resins containing a mixture of bisphenol glycidyl dimethacrylate (BisGMA) and triethylene glycol dimethacrylate (TEGDMA) (75-25%) will be made. Thiourethane oligomers in the proportion of 20% by weight will be used in the resin matrix. A resin composition with only BisGMA/TEGDMA (without the oligomer) will be used as a control. Also 0.25% by weight of camphorquinone (CQ) and 1% by weight of ethyl dimethylamine benzoate (DABE) will be added. Glass particles of 1µm barium-aluminum silicate silanized with methacrylate will be added in variations of 77.4 to 78.3% by weight, according to the concentration of TiO2 nanostructures that are used. TiO2 nanotubes and nanoparticles in two concentrations (0.3 and 0.9%) will be used in the experimental resin composites. Polymerization kinetics and degree of conversion will be evaluated, as well as mechanical properties such as flexural strength, elasticity modulus, microhardness and crosslink density, depth of polymerization and sorption and solubility. Cell viability tests will also be performed to analyze the biocompatibility of the material. The data will be analyzed for normality and homogeneity (Kolmogorov and Smirnov test and Bartlett test, respectively). Having homogeneity and normality, the data will be analyzed using ANOVA and the Tukey multiple comparison test. The level of significance adopted will be 5%. (AU)