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Bioactive dental resins with addition of titanium dioxide nanotubes loaded with alkyl trimethyl ammonium bromide

Grant number: 19/15384-5
Support type:Regular Research Grants
Duration: January 01, 2020 - December 31, 2022
Field of knowledge:Health Sciences - Dentistry - Dental Materials
Cooperation agreement: CONFAP - National Council of State Research Support Foundations
Principal researcher:Marcelo Giannini
Grantee:Marcelo Giannini
Home Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil
Assoc. researchers:Beatriz Ometto Sahadi ; Gabriela de Souza Balbinot ; Isadora Martini Garcia

Abstract

The aim of this study will be to develop an experimental adhesive resin containing titanium dioxide (TiO2) nanotubes with alkyl trimethyl ammonium bromide (ATAB). The TiO2 nanotubes will be synthesized by hydrothermal method; characterized regarding their morphology, by scanning electron microscopy (SEM) and transmission electron microscopy (TEM), and their chemical bonds by infrared (FTIR) and micro-Raman spectroscopies. TiO2 nanotubes will be mixed with ATAB, a quaternary ammonium compound, for filler formulation, which will also be analyzed regarding its morphology and chemical bonds, as well as the ATAB release profile. An experimental adhesive resin will be formulated with 66.66% of bisphenol A glycerolate dimethacrylate (BisGMA) and 33.33% of 2-hydroxyethyl methacrylate (HEMA), in addition to an initiator system. The filler composed of TiO2 nanotubes with ATAB will be added at 1; 2.5 and 5 wt.% into the adhesive resin, in addition to a group without filler addition that will be used as control. The experimental adhesive resins will be evaluated for ATAB release profile, degree of conversion and kinetics of polymerization, contact angle and free surface energy, radiopacity, softening in solvent, immediate and longitudinal flexural strength and modulus of elasticity, mineral deposition, immediate and longitudinal microtensile bond strength, immediate and longitudinal antimicrobial activity, cytotoxicity. The scientific knowledge generated will be transferred in the form of a PhD thesis and will be disseminated through lay press, publication of articles in scientific journals and presentations in scientific congresses. The patent application will be evaluated for the material developed in this study. (AU)

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