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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Green tea prevents vascular disturbs and attenuates periodontal breakdown in long-term hyperglycaemia in T1D rats

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Author(s):
Catanzaro, Daniela Pereira [1] ; Mena Laura, Ever Elias [1] ; Cestari, Tania Mary [1] ; Nunes Arantes, Ricardo Vinicius [1] ; Garlet, Gustavo Pompermaier [1] ; Taga, Rumio [1] ; Assis, Gerson Francisco [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Bauru Sch Dent, Dept Biol Sci, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: JOURNAL OF CLINICAL PERIODONTOLOGY; v. 45, n. 5, p. 557-569, MAY 2018.
Web of Science Citations: 1
Abstract

Aim: The effects of green tea on the modulation of vascularization during the progression of spontaneous periodontitis in long-term hyperglycaemia in streptozotocin-induced type 1 diabetic (T1D) rats were evaluated. Materials and Methods: Wistar rats normoglycaemic (NG) and T1D were divided into two control groups, which received water (NG-W and T1D-W) and two experimental groups that received green tea (NG-GT and T1D-GT). Periodontal structures were evaluated by microtomographic and histological analyses. Number of immunostained cells for VEGF (NcVEGF+/mm(2)) and CD31 (NcCD31+/mm(2)), as well microvessel density (MVD) in the periodontal ligament (PDL) were evaluated. Results: Long-term hyperglycaemia in T1D-W rats induced vascular alterations in PDL with a reduction of 36% in MVD, a decrease of 33% in NcCD31+/mm(2) and an increase of 53% in NcVEGF+/mm(2). Concomitantly, a severe degree of periodontitis with higher reduction in bone volume and periodontal bone level was observed. In T1D-GT, green tea maintained the MVD, NcCD31+/mm(2) and NcVEGF+/mm(2) in the PDL similar to normoglycaemic groups. Clinically, in T1D-GT rats, green tea reduced dental plaque accumulation and the degree of periodontitis when compared to T1D-W. Conclusion: Daily green tea consumption has a therapeutic effect on the diabetic vascular disorder in PDL and the progression of periodontitis in long-term hyperglycaemia in T1D rats. (AU)

FAPESP's process: 12/00680-9 - Immunohistochemical analysis of VEGF protein and microvessel density in the periodontium of diabetic rats treated with green tea
Grantee:Daniela Santos Pereira
Support Opportunities: Scholarships in Brazil - Scientific Initiation