Characteristics, Biological Properties and Analytical Methods of Ursolic Acid: A Review

Author(s)

Pironi, Andressa Maria ^[1] ; de Araujo, Patricia Rocha ^[1] ; Fernandes, Mariza Aires ^[1] ; Nunes Salgado, Herida Regina ^[1] ; Chorilli, Marlus ^[1]

Affiliation

^[1] Sao Paulo State Univ, UNESP, Sch Pharmaceut Sci, Dept Drugs & Med, Araraquara Jau Highway Km 01, BR-14801902 Araraquara, SP - Brazil

• Document type: Review article
• Source: CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY; v. 48, n. 1, p. 86-93, 2018.
• Web of Science Citations: 7

Abstract

Ursolic acid (UA) is a naturally occurring triterpenoid which is a promising candidate for the development of new therapeutic approaches and for the prevention and treatment of several diseases owing to its pharmacological importance. However, its low solubility in aqueous medium affects its therapeutic application. Several strategies have been used to overcome this obstacle. In this study, the incorporation of UA in to different drug delivery systems was found to be highly efficient. In addition, important investigations were performed about methods for qualitative and quantitative analyses of UA in various raw materials, including plants, biological fluids, and drug delivery systems, were investigated. Most recently high performance liquid chromatography coupled with various detectors, gas chromatography-mass spectrometry and capillary electrophoresis were used for this purpose. Thus, this review was performed to evaluate the biological effects of UA demonstrated thus far as well as the currently used, delivery systems and analytical methods. (AU)

• FAPESP's process: 16/22544-0 - Solid dispersions of ursolic acid incorporated in hydrogels to topical administration: development, characterization and in vitro and in vivo biological evaluation
• Grantee: Andressa Maria Pironi
• Support Opportunities: Scholarships in Brazil - Master